Summary of BCL10 mutations
Lymphoma subtypes . | Patient . | Tissue type* . | Template DNA for sequencing† . | Alteration . | Coding exon . | Codon . | Mutations . | Predicted protein size . |
---|---|---|---|---|---|---|---|---|
MALT lymphoma | ||||||||
Low grade | ||||||||
H pylori non-res | 1 | P | p-PCR | 2-bp (GA) del | 3 | 140 | Truncation | 140 |
2 | P | s-PCR | 17-bp del | 3 | 174 | Truncation | 176 | |
3 | P | p-PCR | AAT > GAT | 3 | 173 | ASN > ASP | ||
1-bp (C) del | 3 | 185 | Truncation | 208 | ||||
TCA > TCG | 3 | 189 | Silent | |||||
CCA > CCG | 3 | 204 | Silent | |||||
Others‡ | 4 | F | p-PCR | G > A | 3′ coding exon 2 splicing site | Truncation | 119 | |
5 | F + P | p-PCR | 28-bp del | 3 | 170 | Truncation | 169 | |
6 | F + P | p-PCR | 5-bp del, AGH > AGG | 3 | 218 | Truncation | ||
3 | 181 | Silent | ||||||
High grade | 7 | F | p-PCR | 3-bp del | 3 | 210 | GLU del | 232 |
8 | P | s-PCR | ACC > GCC | 3 | 185 | THR > ALA | 233 | |
GGA > GGG | 3 | 213 | Silent | |||||
CCT > CCC | 3 | 175 | Silent | |||||
Follicular lymphoma | 9 | P | p-PCR | TT ins | 3 | 143 | Truncation | 147 |
10 | F | p-PCR | 17-bp del | 3 | 174 | Truncation | 176 | |
11 | P | p-PCR | 17-bp del | 3 | 174 | Truncation | 176 | |
12 | F | p-PCR | 3-bp del | 3 | 210 | GLU del | 232 | |
DLBCL | 13 | F | p-PCR | 28-bp del | 3 | 170 | Truncation | 169 |
Lymphoma subtypes . | Patient . | Tissue type* . | Template DNA for sequencing† . | Alteration . | Coding exon . | Codon . | Mutations . | Predicted protein size . |
---|---|---|---|---|---|---|---|---|
MALT lymphoma | ||||||||
Low grade | ||||||||
H pylori non-res | 1 | P | p-PCR | 2-bp (GA) del | 3 | 140 | Truncation | 140 |
2 | P | s-PCR | 17-bp del | 3 | 174 | Truncation | 176 | |
3 | P | p-PCR | AAT > GAT | 3 | 173 | ASN > ASP | ||
1-bp (C) del | 3 | 185 | Truncation | 208 | ||||
TCA > TCG | 3 | 189 | Silent | |||||
CCA > CCG | 3 | 204 | Silent | |||||
Others‡ | 4 | F | p-PCR | G > A | 3′ coding exon 2 splicing site | Truncation | 119 | |
5 | F + P | p-PCR | 28-bp del | 3 | 170 | Truncation | 169 | |
6 | F + P | p-PCR | 5-bp del, AGH > AGG | 3 | 218 | Truncation | ||
3 | 181 | Silent | ||||||
High grade | 7 | F | p-PCR | 3-bp del | 3 | 210 | GLU del | 232 |
8 | P | s-PCR | ACC > GCC | 3 | 185 | THR > ALA | 233 | |
GGA > GGG | 3 | 213 | Silent | |||||
CCT > CCC | 3 | 175 | Silent | |||||
Follicular lymphoma | 9 | P | p-PCR | TT ins | 3 | 143 | Truncation | 147 |
10 | F | p-PCR | 17-bp del | 3 | 174 | Truncation | 176 | |
11 | P | p-PCR | 17-bp del | 3 | 174 | Truncation | 176 | |
12 | F | p-PCR | 3-bp del | 3 | 210 | GLU del | 232 | |
DLBCL | 13 | F | p-PCR | 28-bp del | 3 | 170 | Truncation | 169 |