Table 2. Summary of BCL10 mutations... | American Society of Hematology

Table 2.

Summary of BCL10 mutations

Lymphoma subtypes	Patient	Tissue type^*	Template DNA for sequencing^†	Alteration	Coding exon	Codon	Mutations	Predicted protein size
MALT lymphoma
Low grade
H pylori non-res	1	P	p-PCR	2-bp (GA) del	3	140	Truncation	140
	2	P	s-PCR	17-bp del	3	174	Truncation	176
	3	P	p-PCR	AAT > GAT	3	173	ASN > ASP
				1-bp (C) del	3	185	Truncation	208
				TCA > TCG	3	189	Silent
				CCA > CCG	3	204	Silent
Others^‡	4	F	p-PCR	G > A	3′ coding exon 2 splicing site		Truncation	119
	5	F + P	p-PCR	28-bp del	3	170	Truncation	169
	6	F + P	p-PCR	5-bp del, AGH > AGG	3	218	Truncation
					3	181	Silent
High grade	7	F	p-PCR	3-bp del	3	210	GLU del	232
	8	P	s-PCR	ACC > GCC	3	185	THR > ALA	233
				GGA > GGG	3	213	Silent
				CCT > CCC	3	175	Silent
Follicular lymphoma	9	P	p-PCR	TT ins	3	143	Truncation	147
	10	F	p-PCR	17-bp del	3	174	Truncation	176
	11	P	p-PCR	17-bp del	3	174	Truncation	176
	12	F	p-PCR	3-bp del	3	210	GLU del	232
DLBCL	13	F	p-PCR	28-bp del	3	170	Truncation	169

Lymphoma subtypes	Patient	Tissue type^*	Template DNA for sequencing^†	Alteration	Coding exon	Codon	Mutations	Predicted protein size
MALT lymphoma
Low grade
H pylori non-res	1	P	p-PCR	2-bp (GA) del	3	140	Truncation	140
	2	P	s-PCR	17-bp del	3	174	Truncation	176
	3	P	p-PCR	AAT > GAT	3	173	ASN > ASP
				1-bp (C) del	3	185	Truncation	208
				TCA > TCG	3	189	Silent
				CCA > CCG	3	204	Silent
Others^‡	4	F	p-PCR	G > A	3′ coding exon 2 splicing site		Truncation	119
	5	F + P	p-PCR	28-bp del	3	170	Truncation	169
	6	F + P	p-PCR	5-bp del, AGH > AGG	3	218	Truncation
					3	181	Silent
High grade	7	F	p-PCR	3-bp del	3	210	GLU del	232
	8	P	s-PCR	ACC > GCC	3	185	THR > ALA	233
				GGA > GGG	3	213	Silent
				CCT > CCC	3	175	Silent
Follicular lymphoma	9	P	p-PCR	TT ins	3	143	Truncation	147
	10	F	p-PCR	17-bp del	3	174	Truncation	176
	11	P	p-PCR	17-bp del	3	174	Truncation	176
	12	F	p-PCR	3-bp del	3	210	GLU del	232
DLBCL	13	F	p-PCR	28-bp del	3	170	Truncation	169

P, paraffin-embedded tissue; F, frozen tissue.

p-PCR, primary PCR; s-PCR: secondary PCR from SSCP bands.

Low-grade MALT lymphoma without clinical data on H pyloritherapy.

Patients 1, 2, and 3 correspond to patients CF, GP, and CL in Table 1, respectively.