Effect of depletion of Ly-49A+ and Ly-49G2+ NK cells in BALB/c (H2d) on the rejection of H2b allografts
| BMC donor . | H2 . | BMC recipient . | H2 . | Recipient treatment . | Total CFU-c/spleen (×106) . |
|---|---|---|---|---|---|
| C57BL/6 | b | BALB/c | d | NRS | 43 ± 23 |
| 4D11 (anti-Ly-49G2) | 548 ± 180* | ||||
| YE1-48 (anti-Ly-49A) | 40 ± 18 | ||||
| ASGM.1 | 354 ± 67† |
| BMC donor . | H2 . | BMC recipient . | H2 . | Recipient treatment . | Total CFU-c/spleen (×106) . |
|---|---|---|---|---|---|
| C57BL/6 | b | BALB/c | d | NRS | 43 ± 23 |
| 4D11 (anti-Ly-49G2) | 548 ± 180* | ||||
| YE1-48 (anti-Ly-49A) | 40 ± 18 | ||||
| ASGM.1 | 354 ± 67† |
Mice were given various mAb treatments or NRS 2 days before lethal irradiation. Irradiated mice (4 mice/group) received 0.5 × 106 allogeneic BMC. Eight days later a soft-agar colony assay was grown on spleen cells to assess hematopoietic progenitor content.
Values significantly (P < .01) greater than in mice receiving NRS and mAb YE1-48.