Hepatocyte growth factor-modulated gene expression in relation to monocytic function
| Gene . | Function in monocytes . | Modulation factor . | Gene bank accession no. . | |
|---|---|---|---|---|
| Monocytes . | PBMNC . | |||
| MAS proto-oncogene | 1, 7 | 1, 6 | M13150 | |
| Prohibitin | 1, 8 | 2, 1 | S85655 | |
| Protein ETA | 2, 0 | 3, 5 | L20422 | |
| Nitric oxide synthase* | 2, 4 | L09210 | ||
| Lymphotoxin α (TNF β) | 1, 7 | Increased | D12614 | |
| ICH-1 protease | Apoptosis | 2, 2 | Increased | U13021 |
| FAST kinase | 2, 0 | 2, 2 | X86779 | |
| Cysteine protease MCH4 | Apoptosis | 1, 7 | 2, 0 | U60519 |
| HDLC1 | 1, 8 | 3, 8 | U32944 | |
| Replication factor C | Replication | 1, 7 | 5, 2 | M87338 |
| Protein kinase (DNA related) | Transcription? | 1, 7 | Increased | U35835 |
| RAD50 | DNA repair | 2, 1 | Increased | U63139 |
| Calcitonin receptor | 1, 8 | 1, 5 | L00587 | |
| GM-CSF | Growth, proliferation | 2, 6 | M11220 | |
| FMLP-related receptor 1 | Chemokinesis, motility | 2, 3 | M76673 | |
| M-CSF | Proliferation | 1, 7 | M37435 | |
| MIP-1β* | Chemokinesis, motility, migration | 1, 9 | J04130 | |
| MCP-1* | Chemokinesis, motility, migration | 2, 5 | 2, 4 | M24545 |
| VEGF | Growth | 1, 8 | M32977 | |
| Stem cell factor | 1, 8 | 4, 1 | M59964 | |
| Calgranulin B (MIF related)* | Calcium binding in monocytes | 1, 4 | 2, 7 | X06233 |
| MIP-2α* | Chemokinesis, motility, migration | 2, 1 | X53799 | |
| Interleukin 8 | Chemokinesis, motility, migration | 1, 4 | 4, 6 | Y00787 |
| Interleukin 1β | Immune response | 2, 9 | K02770 | |
| Interleukin 4 | Immune response | 1, 9 | M13982 | |
| Interleukin 6 | B-cell differentiation | 1, 6 | 2, 9 | X04602 |
| Interleukin 11 | 1, 8 | M57765 | ||
| IGF-BP | Growth | 1, 7 | 3, 3 | M31159 |
| Proto-oncogene pim-1 | −2, 5 | Complete suppression | M54915 | |
| Tyrosine kinase Lyn | −1, 7 | −1, 8 | M16038 | |
| TNF receptor | −2, 7 | Decreased | M33294 | |
| Basic TF2 | Transcription | −2, 9 | M95809 | |
| SMUBP-2 | DNA binding protein | −2, 0 | L14754 | |
| Interferon-consensus sequence binding protein | DNA binding protein | −3, 8 | M91196 | |
| CNBP | DNA binding protein | −2, 2 | M28372 | |
| CRE-BP1 | DNA binding protein | −2, 0 | L05517 | |
| TSG-6 | TNF inducible protein | −1, 7 | −2, 6 | M31165 |
| Gene . | Function in monocytes . | Modulation factor . | Gene bank accession no. . | |
|---|---|---|---|---|
| Monocytes . | PBMNC . | |||
| MAS proto-oncogene | 1, 7 | 1, 6 | M13150 | |
| Prohibitin | 1, 8 | 2, 1 | S85655 | |
| Protein ETA | 2, 0 | 3, 5 | L20422 | |
| Nitric oxide synthase* | 2, 4 | L09210 | ||
| Lymphotoxin α (TNF β) | 1, 7 | Increased | D12614 | |
| ICH-1 protease | Apoptosis | 2, 2 | Increased | U13021 |
| FAST kinase | 2, 0 | 2, 2 | X86779 | |
| Cysteine protease MCH4 | Apoptosis | 1, 7 | 2, 0 | U60519 |
| HDLC1 | 1, 8 | 3, 8 | U32944 | |
| Replication factor C | Replication | 1, 7 | 5, 2 | M87338 |
| Protein kinase (DNA related) | Transcription? | 1, 7 | Increased | U35835 |
| RAD50 | DNA repair | 2, 1 | Increased | U63139 |
| Calcitonin receptor | 1, 8 | 1, 5 | L00587 | |
| GM-CSF | Growth, proliferation | 2, 6 | M11220 | |
| FMLP-related receptor 1 | Chemokinesis, motility | 2, 3 | M76673 | |
| M-CSF | Proliferation | 1, 7 | M37435 | |
| MIP-1β* | Chemokinesis, motility, migration | 1, 9 | J04130 | |
| MCP-1* | Chemokinesis, motility, migration | 2, 5 | 2, 4 | M24545 |
| VEGF | Growth | 1, 8 | M32977 | |
| Stem cell factor | 1, 8 | 4, 1 | M59964 | |
| Calgranulin B (MIF related)* | Calcium binding in monocytes | 1, 4 | 2, 7 | X06233 |
| MIP-2α* | Chemokinesis, motility, migration | 2, 1 | X53799 | |
| Interleukin 8 | Chemokinesis, motility, migration | 1, 4 | 4, 6 | Y00787 |
| Interleukin 1β | Immune response | 2, 9 | K02770 | |
| Interleukin 4 | Immune response | 1, 9 | M13982 | |
| Interleukin 6 | B-cell differentiation | 1, 6 | 2, 9 | X04602 |
| Interleukin 11 | 1, 8 | M57765 | ||
| IGF-BP | Growth | 1, 7 | 3, 3 | M31159 |
| Proto-oncogene pim-1 | −2, 5 | Complete suppression | M54915 | |
| Tyrosine kinase Lyn | −1, 7 | −1, 8 | M16038 | |
| TNF receptor | −2, 7 | Decreased | M33294 | |
| Basic TF2 | Transcription | −2, 9 | M95809 | |
| SMUBP-2 | DNA binding protein | −2, 0 | L14754 | |
| Interferon-consensus sequence binding protein | DNA binding protein | −3, 8 | M91196 | |
| CNBP | DNA binding protein | −2, 2 | M28372 | |
| CRE-BP1 | DNA binding protein | −2, 0 | L05517 | |
| TSG-6 | TNF inducible protein | −1, 7 | −2, 6 | M31165 |
PBMNC indicates peripheral blood mononuclear cells. “Increased” or “decreased” indicates the tendency of expression; values could not be specified because of a partly high background.
High basic expression (>10-fold the median expression value).