Table 1. Multivariate analysis of... | American Society of Hematology

Table 1.

Multivariate analysis of parameters predicting event-free survival and overall survival

Event-free survival	RR	95% CI	P	Overall survival	RR	95% CI	P
No Δ13	0.5	0.4-0.5	<.0001	No Δ13	0.4	0.4-0.6	<.0001
B2M ≤2.5 mg/L	0.7	0.6-0.8	<.0001	B2M ≤2.5 mg/L	0.6	0.5-0.7	<.0001
≤12 months SDT	0.7	0.6-0.8	<.0001	≤12 mo SDT	0.7	0.6-0.9	.0001
Sensitive to SDT	0.8	0.7-0.9	<.0001	CRP ≤4.0 mg/L	0.7	0.6-0.9	<.0002
Any 2nd HDT^*	0.8	0.6-0.9	.0004	Sensitive to SDT	0.8	0.6-0.9	.0002
Non-IgA isotype	0.7	0.6-0.9	.002	(Days to 2nd HDT)⁻¹ ^*	0.5	0.4-0.6	.001
Any CR^*	0.8	0.6-0.9	.002	Any 2nd HDT^*	0.04	0.01-0.1	<.0001
CRP ≤4.0 mg/L	0.8	0.7-0.9	.03	Non-IgA isotype	0.7	0.6-0.9	.002
(Days to 2nd HDT)⁻¹ ^*			.07	Any CR^*	0.8	0.7-1.0	.04

Event-free survival	RR	95% CI	P	Overall survival	RR	95% CI	P
No Δ13	0.5	0.4-0.5	<.0001	No Δ13	0.4	0.4-0.6	<.0001
B2M ≤2.5 mg/L	0.7	0.6-0.8	<.0001	B2M ≤2.5 mg/L	0.6	0.5-0.7	<.0001
≤12 months SDT	0.7	0.6-0.8	<.0001	≤12 mo SDT	0.7	0.6-0.9	.0001
Sensitive to SDT	0.8	0.7-0.9	<.0001	CRP ≤4.0 mg/L	0.7	0.6-0.9	<.0002
Any 2nd HDT^*	0.8	0.6-0.9	.0004	Sensitive to SDT	0.8	0.6-0.9	.0002
Non-IgA isotype	0.7	0.6-0.9	.002	(Days to 2nd HDT)⁻¹ ^*	0.5	0.4-0.6	.001
Any CR^*	0.8	0.6-0.9	.002	Any 2nd HDT^*	0.04	0.01-0.1	<.0001
CRP ≤4.0 mg/L	0.8	0.7-0.9	.03	Non-IgA isotype	0.7	0.6-0.9	.002
(Days to 2nd HDT)⁻¹ ^*			.07	Any CR^*	0.8	0.7-1.0	.04

Abbreviations: Δ13, chromosome 13 abnormalities; B2M, β-2-microglobulin; CR, complete remission; CRP, C-reactive protein; SDT, standard-dose therapy; HDT, high-dose therapy; RR, relative risk of experiencing event in favorable versus unfavorable categories; CI, confidence interval.

Time-dependent covariate.

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