Hematological parameters of wild-type and β-adducin −/− mice
| Genotype . | +/+ . | +/−* . | −/−† . |
|---|---|---|---|
| n | 11 | 8 | 9 |
| RBC (106/μL) | 9.62 ± 0.08 | 9.71 ± 0.24 | 9.49 ± 0.27 |
| MCH (pg)‡ | 14.75 ± 0.08 | 14.81 ± 0.06‡ | 14.39 ± 0.111-153 |
| MCHC (g/dL)‡ | 30.92 ± 0.16 | 30.74 ± 0.14‡ | 31.40 ± 0.071-153 |
| MCV (fl)1-154 | 47.71 ± 0.25 | 48.20 ± 0.251-154 | 45.83 ± 0.351-154 |
| Hematocrit (%)1-153 | 46.10 ± 0.50 | 46.80 ± 1.201-153 | 43.50 ± 0.601-155 |
| Hemoglobin (g/dL) | 14.25 ± 0.13 | 14.35 ± 0.36 | 13.63 ± 0.191-153 |
| Reticulocytes (%)1-154 | 4.58 ± 0.19 | 5.49 ± 0.24‡,1-155 | 6.76 ± 0.251-154 |
| Genotype . | +/+ . | +/−* . | −/−† . |
|---|---|---|---|
| n | 11 | 8 | 9 |
| RBC (106/μL) | 9.62 ± 0.08 | 9.71 ± 0.24 | 9.49 ± 0.27 |
| MCH (pg)‡ | 14.75 ± 0.08 | 14.81 ± 0.06‡ | 14.39 ± 0.111-153 |
| MCHC (g/dL)‡ | 30.92 ± 0.16 | 30.74 ± 0.14‡ | 31.40 ± 0.071-153 |
| MCV (fl)1-154 | 47.71 ± 0.25 | 48.20 ± 0.251-154 | 45.83 ± 0.351-154 |
| Hematocrit (%)1-153 | 46.10 ± 0.50 | 46.80 ± 1.201-153 | 43.50 ± 0.601-155 |
| Hemoglobin (g/dL) | 14.25 ± 0.13 | 14.35 ± 0.36 | 13.63 ± 0.191-153 |
| Reticulocytes (%)1-154 | 4.58 ± 0.19 | 5.49 ± 0.24‡,1-155 | 6.76 ± 0.251-154 |
All values are X ± SEM. RBC indicates red blood cell; MCHC, main corpuscular hemoglobin concentration; MCV, main corpuscular volume; +/+, +/−, and −/− indicate normal littermate controls, heterozygous, and β-adducin mutant animals, respectively. Statistical analysis was done using the unpaired ANOVA test with the BMDP software.
The P values indicated were obtained when +/− mice were compared with −/− animals, except for the reticulocyte counts were two P values were obtained: P ≤ .01 when +/+ were compared with +/− animals, and P ≤ .005 when +/− were compared with −/− mice.
The P values were obtained when −/− mice were compared with +/+ mice.
P ≤ .01.
P ≤ .05.
P ≤ .005.
P ≤ .0005.