Use of VH gene segments by clonal MALT lesions
| VH segment . | Salivary gland . | Stomach (gastric)3-151 . | ||
|---|---|---|---|---|
| Previous3-150 . | This study . | Total . | ||
| V1-69 (51p1, DP10) | 9/14 (64%) | 8/14 (57%) | 17/28 (61%) | 1/23 (4%) |
| V3-7(HG-19, DP54) | 4/14 (29%) | 1/14 (7%) | 5/28 (18%) | 4/23 (17%) |
| V3-11 (22-2B, DP35) | 1/14 (7%) | 1/14 (7%) | 2/28 (7%) | 0/23 |
| VH segment . | Salivary gland . | Stomach (gastric)3-151 . | ||
|---|---|---|---|---|
| Previous3-150 . | This study . | Total . | ||
| V1-69 (51p1, DP10) | 9/14 (64%) | 8/14 (57%) | 17/28 (61%) | 1/23 (4%) |
| V3-7(HG-19, DP54) | 4/14 (29%) | 1/14 (7%) | 5/28 (18%) | 4/23 (17%) |
| V3-11 (22-2B, DP35) | 1/14 (7%) | 1/14 (7%) | 2/28 (7%) | 0/23 |
MALT = mucosa-associated lymphoid tissue.
The 14 independent clones were identified in a total of 17 biopsy specimens from 10 different patients where 2 biopsies were analyzed for 7 of the patients.4 5 Two patients had 2 salivary biopsies that contained different V1-69 clones, ie, 4 of the 9 “previous” V1-69 VH genes came from 2 patients.
Data from Du et al,19,21 Qin et al,20 Chapman et al,22 and Hallas et al.23