Mutational analysis of consensus salivary gland lymphomaVH genes
Case no. . | GermlineVH gene . | % homology . | CDR1 and 2 . | FW1, 2, and 3 . | ||||||
---|---|---|---|---|---|---|---|---|---|---|
R . | S . | R/S . | Random R/S . | R . | S . | R/S . | Random R/S . | |||
1 | V1-69 | 97 | 4 | 0 | 4 | 3.6 | 3 | 1 | 3 | 3 |
2 | V1-69 | 91 | 6 | 5 | 1.2 | 3.6 | 5 | 11 | 0.45 | 3 |
3 | V1-69 | 98 | 1 | 0 | 1 | 3.6 | 2 | 3 | 0.67 | 3 |
4 | V1-69 | 92 | 6 | 4 | 1.5 | 3.6 | 7 | 7 | 1 | 3 |
5 | V1-69 | 93 | 2 | 5 | 0.4 | 3.6 | 7 | 8 | 0.87 | 3 |
6 | V1-69 | 98 | 3 | 0 | 3 | 3.6 | 1 | 2 | 0.5 | 3 |
7 | V1-69 | 98 | 1 | 3 | 0.3 | 3.6 | 2 | 1 | 2 | 3 |
8 | V1-69 | 97 | 1 | 2 | 0.5 | 3.6 | 4 | 2 | 2 | 3 |
9 | V1-46 | 94 | 6 | 3 | 2 | 4.2 | 1 | 7 | 0.14 | 2.8 |
10 | V3-7 | 98 | 2 | 0 | 2 | 4.9 | 1 | 2 | 0.5 | 2.8 |
11 | V3-30.3 | 100 | ||||||||
12 | V3-11 | 94 | 3 | 1 | 3 | 4.3 | 6 | 8 | 0.75 | 2.8 |
13 | V3-30 | 91 | 5 | 4 | 1.2 | 3.9 | 10 | 7 | 1.4 | 2.8 |
14 | V4-39 | 94 | 4 | 1 | 4 | 4.5 | 7 | 4 | 1.7 | 2.6 |
Case no. . | GermlineVH gene . | % homology . | CDR1 and 2 . | FW1, 2, and 3 . | ||||||
---|---|---|---|---|---|---|---|---|---|---|
R . | S . | R/S . | Random R/S . | R . | S . | R/S . | Random R/S . | |||
1 | V1-69 | 97 | 4 | 0 | 4 | 3.6 | 3 | 1 | 3 | 3 |
2 | V1-69 | 91 | 6 | 5 | 1.2 | 3.6 | 5 | 11 | 0.45 | 3 |
3 | V1-69 | 98 | 1 | 0 | 1 | 3.6 | 2 | 3 | 0.67 | 3 |
4 | V1-69 | 92 | 6 | 4 | 1.5 | 3.6 | 7 | 7 | 1 | 3 |
5 | V1-69 | 93 | 2 | 5 | 0.4 | 3.6 | 7 | 8 | 0.87 | 3 |
6 | V1-69 | 98 | 3 | 0 | 3 | 3.6 | 1 | 2 | 0.5 | 3 |
7 | V1-69 | 98 | 1 | 3 | 0.3 | 3.6 | 2 | 1 | 2 | 3 |
8 | V1-69 | 97 | 1 | 2 | 0.5 | 3.6 | 4 | 2 | 2 | 3 |
9 | V1-46 | 94 | 6 | 3 | 2 | 4.2 | 1 | 7 | 0.14 | 2.8 |
10 | V3-7 | 98 | 2 | 0 | 2 | 4.9 | 1 | 2 | 0.5 | 2.8 |
11 | V3-30.3 | 100 | ||||||||
12 | V3-11 | 94 | 3 | 1 | 3 | 4.3 | 6 | 8 | 0.75 | 2.8 |
13 | V3-30 | 91 | 5 | 4 | 1.2 | 3.9 | 10 | 7 | 1.4 | 2.8 |
14 | V4-39 | 94 | 4 | 1 | 4 | 4.5 | 7 | 4 | 1.7 | 2.6 |
Columns headed with “R” or “S” give the number of deduced replacement or silent mutations from the proposed germlineVH nucleotide sequences, respectively. “Random R/S” refers to the ratio of all possible replacement to silent mutations for the given areas as described by Chang and Casali.31