Percent donor composition of BM after serial transplantation
Genotype
.
Primary
.
Secondary
.
Tertiary
.
Wild-type
94.0 ± 0.7
87.4 ± 7.2
59.3 ± 13.4
Transgene
92.2 ± 0.6
75.9 ± 8.5
63.5 ± 14.8
P value
(.60)
(.34)
(.84)
Genotype
.
Primary
.
Secondary
.
Tertiary
.
Wild-type
94.0 ± 0.7
87.4 ± 7.2
59.3 ± 13.4
Transgene
92.2 ± 0.6
75.9 ± 8.5
63.5 ± 14.8
P value
(.60)
(.34)
(.84)
Mean (±SEM) percent Ly5.2 cells recovered, normalized to equal numbers of donor cells transferred. Numbers of animals of each genotype per group were 5-7. P values are for differences between wild-type and transgene donor engraftment, as represented by percent Ly5.2 cells.