Study design of KF41399 effects on ACNU-induced thrombocytopenia
| Protocol . | KF41399 . | ACNU . | ||||
|---|---|---|---|---|---|---|
| Dose* (mg/kg) . | Schedule (day) . | Frequency . | Dose† (mg/kg) . | Schedule (day) . | Frequency . | |
| A | None | None | ||||
| B | 0.2, 1, 5, 25 | 0-2 | BID | None | ||
| C | 25 | 0-2 | BID | None | ||
| D | 25 | 0-2 | BID | 45 | 3-4 | Daily |
| E | 25 | 2-4 | BID | 45 | 3-4 | Daily |
| F | 25 | 4-6 | BID | 45 | 3-4 | Daily |
| G | 0.2, 1, 5, 25 | 0-2 | BID | 45 | 3-4 | Daily |
| H | 25 | 0-9 | BID | 45 | 3-4 | Daily |
| I | None | 45 | 3-4 | Daily | ||
| Protocol . | KF41399 . | ACNU . | ||||
|---|---|---|---|---|---|---|
| Dose* (mg/kg) . | Schedule (day) . | Frequency . | Dose† (mg/kg) . | Schedule (day) . | Frequency . | |
| A | None | None | ||||
| B | 0.2, 1, 5, 25 | 0-2 | BID | None | ||
| C | 25 | 0-2 | BID | None | ||
| D | 25 | 0-2 | BID | 45 | 3-4 | Daily |
| E | 25 | 2-4 | BID | 45 | 3-4 | Daily |
| F | 25 | 4-6 | BID | 45 | 3-4 | Daily |
| G | 0.2, 1, 5, 25 | 0-2 | BID | 45 | 3-4 | Daily |
| H | 25 | 0-9 | BID | 45 | 3-4 | Daily |
| I | None | 45 | 3-4 | Daily | ||