Tumorigenicity of mouse primary bone marrow cells expressing distinct Bcr-Abl proteins
| Bcr-Abl Form . | Incidence* . | Latency† (d) . | Tumor Mass‡ (g) . |
|---|---|---|---|
| p185 (No 85)2-153,2-155 | 5/5 | 21 | 4.5 ± 0.7 |
| p185 (No 103)2-153,2-155 | 4/4 | 21 | 5.4 ± 0.3 |
| p210 (No 102)2-155 | 0/5 | 150 | 0 |
| p210 (No 106)2-155 | 0/4 | 130 | 0 |
| p230 (No 83)2-155 | 0/5 | 160 | 0 |
| p230 (No 97)2-155,2-154 | 0/8 | 105-127 | 0 |
| p230 (No 105)2-155 | 0/4 | 130 | 0 |
| Bcr-Abl Form . | Incidence* . | Latency† (d) . | Tumor Mass‡ (g) . |
|---|---|---|---|
| p185 (No 85)2-153,2-155 | 5/5 | 21 | 4.5 ± 0.7 |
| p185 (No 103)2-153,2-155 | 4/4 | 21 | 5.4 ± 0.3 |
| p210 (No 102)2-155 | 0/5 | 150 | 0 |
| p210 (No 106)2-155 | 0/4 | 130 | 0 |
| p230 (No 83)2-155 | 0/5 | 160 | 0 |
| p230 (No 97)2-155,2-154 | 0/8 | 105-127 | 0 |
| p230 (No 105)2-155 | 0/4 | 130 | 0 |
Number of mice with tumors/total number of mice injected.
Time in days when tumors were first observed (p185) or time at which animals without tumors were killed (p210 and p230).
Mean mass of tumors ± 1 SD.
All mice injected with p185 Bcr-Abl–expressing primary mouse bone marrow cells developed elevated white blood counts and splenomegaly with circulating GFP-positive lymphoid precursors consistent with the development of lymphoid leukemia.
Indicates independently derived primary mouse bone marrow cultures.
Five mice in this set died on days 105 to 128 but were free of tumor. The remaining 3 mice from this set were killed between days 121 and 127 and were also free from tumor; however, 2 of these mice had elevated white blood counts, splenomegaly, and polycythemia with circulating GFP-positive myeloid cells consistent with the development of a myeloid leukemia.