Platelet production following single bolus injection of 3 μg/kg PEG-rHuMGDF
| . | Day 1 . | Day 8 . | Day 12 . | Day 18 . |
|---|---|---|---|---|
| Platelet turnover | ||||
| (×103plt/μL/d) | 44 ± 12 | 58.3 ± 9.8 | 78.8 ± 26.0 | 101 ± 28 |
| Pvs day 1 | .0008 | .0009 | ||
| Megakaryocyte number | ||||
| (×106/kg) | 13 ± 6.4 | 17 ± 7.5 | 27 ± 9.4 | 11 ± 7.2 |
| Pvs day 1 | .69 | .03 | .69 | |
| Megakaryocyte volume | ||||
| (×103fL) | 30 ± 1.8 | 28 ± 3.0 | 24 ± 3.7 | 26 ± 3.2 |
| Pvs day 1 | .0003 | |||
| Megakaryocyte mass | ||||
| (×1010fL/kg) | 37 ± 19 | 46 ± 19 | 62 ± 17 | 30 ± 18 |
| Pvs day 1 | .42 | .015 |
| . | Day 1 . | Day 8 . | Day 12 . | Day 18 . |
|---|---|---|---|---|
| Platelet turnover | ||||
| (×103plt/μL/d) | 44 ± 12 | 58.3 ± 9.8 | 78.8 ± 26.0 | 101 ± 28 |
| Pvs day 1 | .0008 | .0009 | ||
| Megakaryocyte number | ||||
| (×106/kg) | 13 ± 6.4 | 17 ± 7.5 | 27 ± 9.4 | 11 ± 7.2 |
| Pvs day 1 | .69 | .03 | .69 | |
| Megakaryocyte volume | ||||
| (×103fL) | 30 ± 1.8 | 28 ± 3.0 | 24 ± 3.7 | 26 ± 3.2 |
| Pvs day 1 | .0003 | |||
| Megakaryocyte mass | ||||
| (×1010fL/kg) | 37 ± 19 | 46 ± 19 | 62 ± 17 | 30 ± 18 |
| Pvs day 1 | .42 | .015 |