Baseline data in 30 volunteers in 3 study groups
| . | Placebo (n = 10) . | Erythropoietin, 100 U/kg (n = 10) . | Erythropoietin, 500 U/kg (n = 10) . |
|---|---|---|---|
| Body mass index, kg/m2 | 23 (20-25) | 23 (21-25) | 22 (19-25) |
| Age, y | 27 (20-34) | 28 (20-38) | 27 (20-37) |
| Ferritin, μg/L | 122 (66-387) | 115 (67-202) | 105 (64-172) |
| Erythropoietin, IU/L | 5.7 (2.4-10.4) | 5.2 (2.4-13.3) | 4.0 (2.4-8.1) |
| Hemoglobin, g/L | 143 (129-157) | 140 (128-153) | 146 (130-166) |
| Mean corpuscular volume, fl | 85 (79-89) | 88 (80-95) | 87 (83-90) |
| Reticulocytes, 109/L | 57 (32-88) | 42 (25-61) | 52 (27-89) |
| Highly fluorescent reticulocytes, % | 0.4 (0.1-1) | 0.4 (0.1-0.9) | 0.5 (0.1-1.1) |
| Platelets, 109/L | 203 (150-266) | 217 (175-260) | 206 (153-273) |
| Reticulated platelets, % | 2.2 (0.9-3.6) | 2.1 (1.0-3.7) | 2.1 (0.9-2.6) |
| CFU-GM, cells/mL | 342 (83-819) | 279 (46-606) | 378 (90-854) |
| BFU-E, 103 cells/mL | 1.0 (0.3-2.2) | 0.8 (0.1-1.3) | 1.2 (0.3-2.7) |
| CFU-GEMM, cells/mL | 38 (6-116) | 30 (0-62) | 59 (0-177) |
| CFU-MK, cells/mL | 37 (0-143) | 28 (0-112) | 23 (4-43) |
| Circulating P-selectin, μg/L | 28 (18-44) | 36 (20-73) | 35 (21-46) |
| Circulating E-selectin, μg/L | 30 (18-51) | 45 (23-71) | 32 (18-45) |
| . | Placebo (n = 10) . | Erythropoietin, 100 U/kg (n = 10) . | Erythropoietin, 500 U/kg (n = 10) . |
|---|---|---|---|
| Body mass index, kg/m2 | 23 (20-25) | 23 (21-25) | 22 (19-25) |
| Age, y | 27 (20-34) | 28 (20-38) | 27 (20-37) |
| Ferritin, μg/L | 122 (66-387) | 115 (67-202) | 105 (64-172) |
| Erythropoietin, IU/L | 5.7 (2.4-10.4) | 5.2 (2.4-13.3) | 4.0 (2.4-8.1) |
| Hemoglobin, g/L | 143 (129-157) | 140 (128-153) | 146 (130-166) |
| Mean corpuscular volume, fl | 85 (79-89) | 88 (80-95) | 87 (83-90) |
| Reticulocytes, 109/L | 57 (32-88) | 42 (25-61) | 52 (27-89) |
| Highly fluorescent reticulocytes, % | 0.4 (0.1-1) | 0.4 (0.1-0.9) | 0.5 (0.1-1.1) |
| Platelets, 109/L | 203 (150-266) | 217 (175-260) | 206 (153-273) |
| Reticulated platelets, % | 2.2 (0.9-3.6) | 2.1 (1.0-3.7) | 2.1 (0.9-2.6) |
| CFU-GM, cells/mL | 342 (83-819) | 279 (46-606) | 378 (90-854) |
| BFU-E, 103 cells/mL | 1.0 (0.3-2.2) | 0.8 (0.1-1.3) | 1.2 (0.3-2.7) |
| CFU-GEMM, cells/mL | 38 (6-116) | 30 (0-62) | 59 (0-177) |
| CFU-MK, cells/mL | 37 (0-143) | 28 (0-112) | 23 (4-43) |
| Circulating P-selectin, μg/L | 28 (18-44) | 36 (20-73) | 35 (21-46) |
| Circulating E-selectin, μg/L | 30 (18-51) | 45 (23-71) | 32 (18-45) |
CFU-GM indicates colony-forming units-granulocyte, macrophage; BFU-E, burst-forming units-erythroid; CFU-GEMM, colony-forming units-granulocyte, erythrocyte, megakaryocyte, and macrophage; and CFU-MK, colony-forming units-megakaryocytes. Data are expressed as mean (range).