Analysis of VH gene mutations in follicular lymphomas
| Patient No. . | Total No. of Mutations . | Observed Mutations in the Framework Region . | P3-150 Value . | ||
|---|---|---|---|---|---|
| R . | S . | R/S . | |||
| 1 | 12 | 2 | 2 | 1.0 | <.01 |
| 3-′93 | 26 | 9 | 8 | 1.1 | <.05 |
| 3-′95 | 21 | 4 | 6 | 0.7 | <.001 |
| 13 | 9 | 3 | 2 | 1.5 | 0.095 |
| 15 | 8 | 0 | 2 | 0 | — |
| 16 | 49 | 15 | 14 | 1.1 | <.001 |
| 17 | 16 | 0 | 3 | 0 | — |
| 18 | 26 | 9 | 8 | 1.1 | <.05 |
| 32 | 26 | 8 | 10 | 0.8 | <.01 |
| 57 | 25 | 5 | 11 | 0.5 | <.001 |
| 58 | 26 | 6 | 8 | 0.8 | <.001 |
| 67 | 25 | 6 | 10 | 0.6 | <.01 |
| 8-′83μ | 30 | 9 | 9 | 1.0 | <.01 |
| 8-′83γ | 35 | 10 | 11 | 0.9 | <.001 |
| 8-′92 | 35 | 10 | 13 | 0.8 | <.001 |
| 2 | 37 | 14 | 12 | 1.2 | <.01 |
| 4 | 49 | 15 | 14 | 1.1 | <.001 |
| 5 | 20 | 7 | 4 | 1.8 | <.05 |
| 6-′94 | 44 | 7 | 15 | 0.5 | <.05 |
| 6-′98 | 50 | 8 | 20 | 0.4 | <.001 |
| 25 | 20 | 3 | 7 | 0.4 | <.001 |
| 35 | 34 | 11 | 10 | 1.1 | <.01 |
| 50 | 51 | 23 | 12 | 1.9 | <.05 |
| 52 | 42 | 14 | 14 | 1.0 | <.001 |
| 56 | 26 | 7 | 9.0 | 0.8 | <.01 |
| 59 | 11 | 9 | 1.0 | 9 | 0.083 |
| 66-′96 | 38 | 16 | 10 | 1.6 | <.05 |
| 66-′97 | 39 | 15 | 10 | 1.5 | <.05 |
| 66-′98 | 40 | 16 | 11 | 1.5 | <.05 |
| 68 | 8 | 2 | 3 | 0.7 | .055 |
| 49 | 29 | 7 | 8 | 0.9 | <.001 |
| Patient No. . | Total No. of Mutations . | Observed Mutations in the Framework Region . | P3-150 Value . | ||
|---|---|---|---|---|---|
| R . | S . | R/S . | |||
| 1 | 12 | 2 | 2 | 1.0 | <.01 |
| 3-′93 | 26 | 9 | 8 | 1.1 | <.05 |
| 3-′95 | 21 | 4 | 6 | 0.7 | <.001 |
| 13 | 9 | 3 | 2 | 1.5 | 0.095 |
| 15 | 8 | 0 | 2 | 0 | — |
| 16 | 49 | 15 | 14 | 1.1 | <.001 |
| 17 | 16 | 0 | 3 | 0 | — |
| 18 | 26 | 9 | 8 | 1.1 | <.05 |
| 32 | 26 | 8 | 10 | 0.8 | <.01 |
| 57 | 25 | 5 | 11 | 0.5 | <.001 |
| 58 | 26 | 6 | 8 | 0.8 | <.001 |
| 67 | 25 | 6 | 10 | 0.6 | <.01 |
| 8-′83μ | 30 | 9 | 9 | 1.0 | <.01 |
| 8-′83γ | 35 | 10 | 11 | 0.9 | <.001 |
| 8-′92 | 35 | 10 | 13 | 0.8 | <.001 |
| 2 | 37 | 14 | 12 | 1.2 | <.01 |
| 4 | 49 | 15 | 14 | 1.1 | <.001 |
| 5 | 20 | 7 | 4 | 1.8 | <.05 |
| 6-′94 | 44 | 7 | 15 | 0.5 | <.05 |
| 6-′98 | 50 | 8 | 20 | 0.4 | <.001 |
| 25 | 20 | 3 | 7 | 0.4 | <.001 |
| 35 | 34 | 11 | 10 | 1.1 | <.01 |
| 50 | 51 | 23 | 12 | 1.9 | <.05 |
| 52 | 42 | 14 | 14 | 1.0 | <.001 |
| 56 | 26 | 7 | 9.0 | 0.8 | <.01 |
| 59 | 11 | 9 | 1.0 | 9 | 0.083 |
| 66-′96 | 38 | 16 | 10 | 1.6 | <.05 |
| 66-′97 | 39 | 15 | 10 | 1.5 | <.05 |
| 66-′98 | 40 | 16 | 11 | 1.5 | <.05 |
| 68 | 8 | 2 | 3 | 0.7 | .055 |
| 49 | 29 | 7 | 8 | 0.9 | <.001 |
P indicates probability that the number of R mutations observed in the FRs was obtained by chance.
P values in boldface type indicate significance (P < .05).
See Chang and Casali.30