Table 2. Frequency (in percent) of... | American Society of Hematology

Table 2.

Frequency (in percent) of TER-119⁺ and/or 4A5⁺ cells in the marrow and spleens of normal mice and of mice recovering from the anemia induced by phenylhydrazine (PHZ; day 1-3)

	Bone Marrow			Spleen^*
	TER-119⁺	4A5⁺	TER-119⁺/4A5⁺	TER-119⁺	4A5⁺	TER-119⁺/4A5⁺
Normal mice	7.5 ± 1.6	0.6 ± 0.3	1.3 ± 0.6	1.2 ± 0.8	0.1 ± 0.05	< 0.001
PHZ-treated mice
Day 1	13.8 ± 3.2^†	2.4 ± 1.0^†	3.8 ± 0.8^‡	10.2 ± 0.2^†	0.8 ± 0.5^†	1.3 ± 0.3^†
Day 2	25.3 ± 4.7^†	1.1 ± 0.6	4.7 ± 1.3^‡	11.2 ± 2.1^†	1.9 ± 0.8^†	5.3 ± 0.6^†
Day 3	18.5 ± 2.1^†	0.4 ± 0.2	3.8 ± 0.7^‡	18.0 ± 3.1^†	0.5 ± 0.2	8.3 ± 1.7^†

	Bone Marrow			Spleen^*
	TER-119⁺	4A5⁺	TER-119⁺/4A5⁺	TER-119⁺	4A5⁺	TER-119⁺/4A5⁺
Normal mice	7.5 ± 1.6	0.6 ± 0.3	1.3 ± 0.6	1.2 ± 0.8	0.1 ± 0.05	< 0.001
PHZ-treated mice
Day 1	13.8 ± 3.2^†	2.4 ± 1.0^†	3.8 ± 0.8^‡	10.2 ± 0.2^†	0.8 ± 0.5^†	1.3 ± 0.3^†
Day 2	25.3 ± 4.7^†	1.1 ± 0.6	4.7 ± 1.3^‡	11.2 ± 2.1^†	1.9 ± 0.8^†	5.3 ± 0.6^†
Day 3	18.5 ± 2.1^†	0.4 ± 0.2	3.8 ± 0.7^‡	18.0 ± 3.1^†	0.5 ± 0.2	8.3 ± 1.7^†

For spleen, the frequency was analyzed on light density cell fraction to reduce erythroblast interference with cytometric analysis. The total number of cells per spleen was as follows: 60-80 × 10⁶ (normal spleen), 150-250 × 10⁶ (day 1 PHZ-spleen), and 300-400 × 10⁶ (day 3 PHZ-spleen). The results are expressed as mean (± SD) of 5 separate analyses.

†

P < .05 with respect to the values observed in normal mice.

‡

P < .01 with respect to the values observed in normal mice.

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