Patient characteristics: URD BMT recipients with CML
| . | N . | (%) . |
|---|---|---|
| Recipient age* | % | |
| 20 years or younger | 162 | (11) |
| 21-30 | 286 | (20) |
| 31-40 | 477 | (34) |
| 41-50 | 418 | (29) |
| 51+ | 80 | (6) |
| Gender (donor:recipient)† | ||
| M:F | 288 | (20) |
| M:M | 523 | (37) |
| F:F | 289 | (20) |
| F:M | 322 | (23) |
| Female donor (parous) | 345 | (57) |
| Female donor (nulliparous) | 266 | (43) |
| BMT within 12 months of diagnosis‡ | 452 | (32%) |
| Stage at BMT | ||
| CP1 | 916 | (65) |
| CP2+ | 97 | (7) |
| AP | 301 | (21) |
| BC | 101 | (7) |
| Missing | 8 | |
| Pre-BMT conditioning | ||
| TBI + Cy ± other | 1222 | (86) |
| Chemotherapy only | 201 | (14) |
| CMV serology pre-BMT | ||
| Recipient+; Donor+ or − | 659 | (49) |
| R−; D+ | 231 | (17) |
| R−; D− | 466 | (34) |
| GVHD prophylaxis | ||
| CSA/other | 957 | (68) |
| T-depletion (ex vivo) | 329 | (23) |
| Other | 127 | (9) |
| HLA matching | ||
| HLA-A, B, DR matched | 1150 | (81) |
| 1 A-locus mismatch; B, DR matched | 123 | (9) |
| 1 B-locus mismatch; A, DR matched | 107 | (8) |
| 1 DR-locus mismatch; A, B matched | 40 | (3) |
| . | N . | (%) . |
|---|---|---|
| Recipient age* | % | |
| 20 years or younger | 162 | (11) |
| 21-30 | 286 | (20) |
| 31-40 | 477 | (34) |
| 41-50 | 418 | (29) |
| 51+ | 80 | (6) |
| Gender (donor:recipient)† | ||
| M:F | 288 | (20) |
| M:M | 523 | (37) |
| F:F | 289 | (20) |
| F:M | 322 | (23) |
| Female donor (parous) | 345 | (57) |
| Female donor (nulliparous) | 266 | (43) |
| BMT within 12 months of diagnosis‡ | 452 | (32%) |
| Stage at BMT | ||
| CP1 | 916 | (65) |
| CP2+ | 97 | (7) |
| AP | 301 | (21) |
| BC | 101 | (7) |
| Missing | 8 | |
| Pre-BMT conditioning | ||
| TBI + Cy ± other | 1222 | (86) |
| Chemotherapy only | 201 | (14) |
| CMV serology pre-BMT | ||
| Recipient+; Donor+ or − | 659 | (49) |
| R−; D+ | 231 | (17) |
| R−; D− | 466 | (34) |
| GVHD prophylaxis | ||
| CSA/other | 957 | (68) |
| T-depletion (ex vivo) | 329 | (23) |
| Other | 127 | (9) |
| HLA matching | ||
| HLA-A, B, DR matched | 1150 | (81) |
| 1 A-locus mismatch; B, DR matched | 123 | (9) |
| 1 B-locus mismatch; A, DR matched | 107 | (8) |
| 1 DR-locus mismatch; A, B matched | 40 | (3) |
AP = accelerated phase; BC = blast crisis; BMT = bone marrow transplant; CML = chronic myelogenous leukemia; CMV = cytomegalovirus; CP = chronic phase; CSA = cyclosporine A; Cy = cyclophosphamide; GVHD = graft-versus-host disease; TBI = total body irradiation; URD = unrelated donor.
Median recipient age, 35 y; range, 1.9-59.
Median donor age, 38 y; range, 18-57.
Median interval from diagnosis to BMT, 18 mo; range, 2.9-325 mo.