Characteristics of patients with loss of heterozygosity for 5q13.3 loci
| Patient Number . | Karyotype . | Age/Gender . | Diagnosis . | Previous Malignancy . |
|---|---|---|---|---|
| 1 | 45 XX, −5, add(17)(p11.2)[5] | 37/F | Secondary RAEB-t | Yes |
| 42-45 XX, −3, −5, add(6)(p25), −7, −14, −15, add(17)(p11.2), +2 mar [15] | ||||
| 2 | 45 XX, del(5)(q14), del(7)(q21q31), del(9)(q11q22), add(11)(p15), −16, add(17)(p11) | 39/F | De novo AML (M1) | No |
| 3 | 45 XX, various karyotypic changes including ins(3;5)(q31;q31), del(5)(q11q31), dup(8q), t(12;13)(p13;q14) | ??/M | Secondary AML | Yes |
| 4* | 45-48 XY, −2, −5, t(5;12), del(7)(q?), +8, −16, +1-2 r, +1-4 mar[16] 46 XY[4] | 82/M | RAEB-t | Yes |
| Patient Number . | Karyotype . | Age/Gender . | Diagnosis . | Previous Malignancy . |
|---|---|---|---|---|
| 1 | 45 XX, −5, add(17)(p11.2)[5] | 37/F | Secondary RAEB-t | Yes |
| 42-45 XX, −3, −5, add(6)(p25), −7, −14, −15, add(17)(p11.2), +2 mar [15] | ||||
| 2 | 45 XX, del(5)(q14), del(7)(q21q31), del(9)(q11q22), add(11)(p15), −16, add(17)(p11) | 39/F | De novo AML (M1) | No |
| 3 | 45 XX, various karyotypic changes including ins(3;5)(q31;q31), del(5)(q11q31), dup(8q), t(12;13)(p13;q14) | ??/M | Secondary AML | Yes |
| 4* | 45-48 XY, −2, −5, t(5;12), del(7)(q?), +8, −16, +1-2 r, +1-4 mar[16] 46 XY[4] | 82/M | RAEB-t | Yes |
RAEB-t = refractory anemia with excess blasts in transformation; AML = acute myelogenous leukemia.
No cytogenetic abnormality of chromosome 17.