MUM1 protein expression in paraffin sections of human lymphomas
| Type . | Cases (N = 150) . | MUM1 Expression by Tumor Cells (%) . |
|---|---|---|
| B-cell derived | ||
| Acute lymphoblastic leukemia | 5 | 0/5 |
| Chronic lymphocytic leukemia | 15 | 10/153-150 |
| Hairy cell leukemia | 6 | 0/6 |
| Mantle cell lymphoma | 6 | 2/63-151 (30%-50%) |
| Marginal zone lymphoma | 3 | 2/33-152 (30%-50%) |
| FCC lymphoma | 15 | 1/153-153 |
| DLCL-B | 30 | 23/30 (30%-100%) |
| Burkitt lymphoma | 3 | 0/3 |
| Myeloma | 15 | 15/15 (100%) |
| T-cell derived | ||
| Acute lymphoblastic leukemia | 5 | 0/5 |
| PTCL-NOS | 3 | 1/3 (30%) |
| PTCL-lymphoepit. | 2 | 1/2 (10%) |
| PTCL-AILD | 5 | 5/5 (10%-20%) |
| PTCL-intestinal | 3 | 1/3 (100%) |
| ATL | 3 | 3/3 (10%-40%) |
| Mycosis fungoides | 5 | 2/5 (40%) |
| Anaplastic large cell lymphoma | 10 | 10/10 (100%) |
| Hodgkin's disease | ||
| Lymphocyte predominance | 2 | 2/2 (100%) |
| Nodular sclerosis | 9 | 9/9 (100%) |
| Mixed cellularity | 5 | 5/5 (100%) |
| Type . | Cases (N = 150) . | MUM1 Expression by Tumor Cells (%) . |
|---|---|---|
| B-cell derived | ||
| Acute lymphoblastic leukemia | 5 | 0/5 |
| Chronic lymphocytic leukemia | 15 | 10/153-150 |
| Hairy cell leukemia | 6 | 0/6 |
| Mantle cell lymphoma | 6 | 2/63-151 (30%-50%) |
| Marginal zone lymphoma | 3 | 2/33-152 (30%-50%) |
| FCC lymphoma | 15 | 1/153-153 |
| DLCL-B | 30 | 23/30 (30%-100%) |
| Burkitt lymphoma | 3 | 0/3 |
| Myeloma | 15 | 15/15 (100%) |
| T-cell derived | ||
| Acute lymphoblastic leukemia | 5 | 0/5 |
| PTCL-NOS | 3 | 1/3 (30%) |
| PTCL-lymphoepit. | 2 | 1/2 (10%) |
| PTCL-AILD | 5 | 5/5 (10%-20%) |
| PTCL-intestinal | 3 | 1/3 (100%) |
| ATL | 3 | 3/3 (10%-40%) |
| Mycosis fungoides | 5 | 2/5 (40%) |
| Anaplastic large cell lymphoma | 10 | 10/10 (100%) |
| Hodgkin's disease | ||
| Lymphocyte predominance | 2 | 2/2 (100%) |
| Nodular sclerosis | 9 | 9/9 (100%) |
| Mixed cellularity | 5 | 5/5 (100%) |
FCC, follicle center lymphoma; DLCL-B, diffuse large B-cell lymphoma; PTCL, peripheral T-cell lymphoma; NOS, not otherwise specified; Lymphoepit, lymphoepithelioid type; AILD, angioimmunoblastic lymphadenopathy type; intestinal, enteropathy-type intestinal T-cell lymphoma; ATL, adult T-cell lymphoma/leukemia. The numbers in parentheses indicate the percentage of MUM1+ tumor cells.
Moderate positivity of prolymphocytes and paraimmunoblasts in pseudofollicles; weak nuclear staining is observed in the small neoplastic cells.
Usually weak nuclear staining.
Nuclear positivity is seen especially in cells with plasmacytoid morphology.
Strong positivity of tumor cells in FCC lymphoma, grade III.