Details of human chemokine receptors described until June 1999
| Receptor . | Amino acids . | Base pairs . | Ligand (high affinity) . | Cellular distribution . |
|---|---|---|---|---|
| XCR1 (GPR5) | 333 | 999 | Lymphotactin | T, B, NK |
| CXCR1 (IL8RA) | 350 | 1050 | IL8, GCP-2 | N, M, T, NK, Bs, Ms, En |
| CXCR2 (IL8RB) | 355 | 1065 | IL8, GRO-α, GRO-β, GRO-γ, NAP-2, ENA-78, GCP-2 | N, M, T, NK, MS, As, Nn, Ms, En |
| CXCR3 | 368 | 1104 | IP-10, Mig, I-TAC | Activated T |
| CXCR4* (LESTR, FUSIN) | 352 | 1056 | SDF-1α, SDF-1β | Myeloid, T, B, Ep, En, DC |
| CXCR5 (BLR1) | 372 | 1116 | BCA-1 | B |
| CX3CR1 (V28) | 355 | 1065 | Fractalkine | NK, M, T |
| CCR1 | 355 | 1065 | RANTES, MIP-1α, HCC-1, MCP-2, MCP-3, MIP-5, Ckβ8, | N, M, T, NK, B, Ms, As, Nn |
| CCR2A | 374 | 1122 | MCP-1, MCP-3, MCP-4 | M |
| CCR2B† | 360 | 1080 | MCP-1, MCP-2, MCP-3, MCP-4 | M, T, B, Bs |
| CCR3† | 355 | 1065 | Eotaxin, Eotaxin-2, Eotaxin-3, RANTES, MCP-2,3,4, MIP-5, | Eo, Bs, T |
| CCR4 | 360 | 1080 | TARC, MDC | T, P |
| CCR5† (ChemR13) | 352 | 1056 | RANTES, MIP-1β, MIP-1α, MCP-2 | T, M, M∅︀, DC |
| CCR6 (STRL 22, DRY-6, GPR-CY4, CKR-L3) | 374 | 1122 | MIP-3α | T, B, DC |
| CCR7 (BRL2, EBI1) | 378 | 1134 | MIP-3β, 6-C-kine, | T, B, DC |
| CCR8*,† (TER1, CKR-L1, ChemR1) | 355 | 1065 | I-309 | M, Thymus |
| CCR9 (GPR-9-6) | 369 | 1107 | TECK | T, Thymus |
| D6 (CCR10?) | 384 | 1152 | MCP-1, MCP-3 | placenta, liver |
| DARC (Duffy antigen) | 338 | 1014 | IL-8, GRO-α, RANTES, MCP-1, MCP-3, MCP-4, Eotaxin | En, RBC, T |
| Receptor . | Amino acids . | Base pairs . | Ligand (high affinity) . | Cellular distribution . |
|---|---|---|---|---|
| XCR1 (GPR5) | 333 | 999 | Lymphotactin | T, B, NK |
| CXCR1 (IL8RA) | 350 | 1050 | IL8, GCP-2 | N, M, T, NK, Bs, Ms, En |
| CXCR2 (IL8RB) | 355 | 1065 | IL8, GRO-α, GRO-β, GRO-γ, NAP-2, ENA-78, GCP-2 | N, M, T, NK, MS, As, Nn, Ms, En |
| CXCR3 | 368 | 1104 | IP-10, Mig, I-TAC | Activated T |
| CXCR4* (LESTR, FUSIN) | 352 | 1056 | SDF-1α, SDF-1β | Myeloid, T, B, Ep, En, DC |
| CXCR5 (BLR1) | 372 | 1116 | BCA-1 | B |
| CX3CR1 (V28) | 355 | 1065 | Fractalkine | NK, M, T |
| CCR1 | 355 | 1065 | RANTES, MIP-1α, HCC-1, MCP-2, MCP-3, MIP-5, Ckβ8, | N, M, T, NK, B, Ms, As, Nn |
| CCR2A | 374 | 1122 | MCP-1, MCP-3, MCP-4 | M |
| CCR2B† | 360 | 1080 | MCP-1, MCP-2, MCP-3, MCP-4 | M, T, B, Bs |
| CCR3† | 355 | 1065 | Eotaxin, Eotaxin-2, Eotaxin-3, RANTES, MCP-2,3,4, MIP-5, | Eo, Bs, T |
| CCR4 | 360 | 1080 | TARC, MDC | T, P |
| CCR5† (ChemR13) | 352 | 1056 | RANTES, MIP-1β, MIP-1α, MCP-2 | T, M, M∅︀, DC |
| CCR6 (STRL 22, DRY-6, GPR-CY4, CKR-L3) | 374 | 1122 | MIP-3α | T, B, DC |
| CCR7 (BRL2, EBI1) | 378 | 1134 | MIP-3β, 6-C-kine, | T, B, DC |
| CCR8*,† (TER1, CKR-L1, ChemR1) | 355 | 1065 | I-309 | M, Thymus |
| CCR9 (GPR-9-6) | 369 | 1107 | TECK | T, Thymus |
| D6 (CCR10?) | 384 | 1152 | MCP-1, MCP-3 | placenta, liver |
| DARC (Duffy antigen) | 338 | 1014 | IL-8, GRO-α, RANTES, MCP-1, MCP-3, MCP-4, Eotaxin | En, RBC, T |
T-lymphocyte[en]tropic HIV-1 coreceptor.
Macrophage-tropic HIV-1 coreceptor.
Previous chemokine receptor names are given in brackets.
N, neutrophil; M, monocyte/macrophage; T, T-lymphocyte; B, B-lymphocyte; NK, natural killer cell; Eo, eosinophil; Bs, basophil; Ms, mast cell; As, astrocyte; Nn, neurone; P, platelet; En, endothelial cell; Ep, epithelial cell; Hp, hepatocyte; DC, dendritic cell; M∅︀, macrophage; RBC, erythrocyte.