Incidence and mortality for cancer in ALD patients' families
| Incidence . | Observed/Expected . | Standardized Incidence Ratio (95% confidence interval) . | ||||
|---|---|---|---|---|---|---|
| Total . | Males . | Females . | Total . | Males . | Females . | |
| Both parents | 18/14.8 | 10/9 | 8/5.8 | 1.22 (0.72-1.92) | 1.11 (0.53-2.04) | 1.38 (0.59-2.72) |
| Paternal lineage | 4/7.8 | 4/5 | 0/2.8 | 0.51 (0.14-1.31) | 0.80 (0.22-2.05) | 0 (0-1.31) |
| Maternal lineage | 13/6.93-150 | 5/3.9 | 8/3.03-150 | 1.88 (1-3.22) | 1.28 (0.41-2.99) | 2.67 (1.15-5.25) |
| Mortality | Observed/Expected | Standardized Mortality Ratio (95% confidence interval) | ||||
| Total | Males | Females | Total | Males | Females | |
| Both parents | 11/7.4 | 6/5 | 5/2.3 | 1.49 (0.74-2.66) | 1.20 (0.44-2.61) | 2.17 (0.7-5.07) |
| Paternal lineage | 2/4.1 | 2/2.8 | 0/1.3 | 0.49 (0.05-1.76) | 0.71 (0.08-2.58) | 0 (0-2.83) |
| Maternal lineage | 9/3.33-150 | 4/2.2 | 5/1.13-150 | 2.73 (1.24-5.18) | 1.82 (0.49-4.65) | 4.55 (1.46-10.61) |
| Incidence . | Observed/Expected . | Standardized Incidence Ratio (95% confidence interval) . | ||||
|---|---|---|---|---|---|---|
| Total . | Males . | Females . | Total . | Males . | Females . | |
| Both parents | 18/14.8 | 10/9 | 8/5.8 | 1.22 (0.72-1.92) | 1.11 (0.53-2.04) | 1.38 (0.59-2.72) |
| Paternal lineage | 4/7.8 | 4/5 | 0/2.8 | 0.51 (0.14-1.31) | 0.80 (0.22-2.05) | 0 (0-1.31) |
| Maternal lineage | 13/6.93-150 | 5/3.9 | 8/3.03-150 | 1.88 (1-3.22) | 1.28 (0.41-2.99) | 2.67 (1.15-5.25) |
| Mortality | Observed/Expected | Standardized Mortality Ratio (95% confidence interval) | ||||
| Total | Males | Females | Total | Males | Females | |
| Both parents | 11/7.4 | 6/5 | 5/2.3 | 1.49 (0.74-2.66) | 1.20 (0.44-2.61) | 2.17 (0.7-5.07) |
| Paternal lineage | 2/4.1 | 2/2.8 | 0/1.3 | 0.49 (0.05-1.76) | 0.71 (0.08-2.58) | 0 (0-2.83) |
| Maternal lineage | 9/3.33-150 | 4/2.2 | 5/1.13-150 | 2.73 (1.24-5.18) | 1.82 (0.49-4.65) | 4.55 (1.46-10.61) |
Statistically significant.