Table 2. Frequency of autoimmune... | American Society of Hematology

Table 2.

Frequency of autoimmune diseases in families of ALD patients

	ALD Families		Control Families		P Value
	Cases/Total^*	%^† (CI)^‡	Cases/Total^*	%^†	P Value
Total	10/108	9.3 (4.5-16.4)	6/235	2.6 (0.9-5.5)	.014^2-153
Males	6/54	11.1 (4.2-22.6)	1/123	0.8 (0.02-4.4)	.0035^2-153
Females	4/54	7.4 (2.1-17.9)	5/112	4.5 (1.5-10.1)
Paternal lineage	9/46	19.6 (9.4-33.9)	2/117	1.7 (0.2-6.1)	.0002^2-155
Males	6/32	18.8 (7.2-36.4)	1/70	1.4 (0.03-7.7)	.0036^2-155
Females	3/14	21.4 (4.7-50.8)	1/47	2.1 (0.05-11.3)	.035^2-155
Maternal lineage	1/52	1.9 (0.04-10.3)	4/102	3.9 (1.1-9.7)
Males	0/17	0 (0-19.5)	0/44	0 (0-8.1)
Females	1/35	2.8 (0.1-14.9)	4/58	6.7 (1.9-16.7)

	ALD Families		Control Families		P Value
	Cases/Total^*	%^† (CI)^‡	Cases/Total^*	%^†	P Value
Total	10/108	9.3 (4.5-16.4)	6/235	2.6 (0.9-5.5)	.014^2-153
Males	6/54	11.1 (4.2-22.6)	1/123	0.8 (0.02-4.4)	.0035^2-153
Females	4/54	7.4 (2.1-17.9)	5/112	4.5 (1.5-10.1)
Paternal lineage	9/46	19.6 (9.4-33.9)	2/117	1.7 (0.2-6.1)	.0002^2-155
Males	6/32	18.8 (7.2-36.4)	1/70	1.4 (0.03-7.7)	.0036^2-155
Females	3/14	21.4 (4.7-50.8)	1/47	2.1 (0.05-11.3)	.035^2-155
Maternal lineage	1/52	1.9 (0.04-10.3)	4/102	3.9 (1.1-9.7)
Males	0/17	0 (0-19.5)	0/44	0 (0-8.1)
Females	1/35	2.8 (0.1-14.9)	4/58	6.7 (1.9-16.7)

Subjects with autoimmune disease/total subjects observed. These counts do not include the patients.

Percentage of subjects with autoimmune disease.

95% confidence interval.

Chi-square test.

Fisher exact test.