Table 1.

Outcome of unmodified donor lymphocyte infusion (DLI) in mixed chimeric recipients

Dog Conditioning (Gy)% Donor chimerism before DLI Day of DLICD3+ cells infused (×107/kg) % Donor chimerism after DLI*
PBMC PBG PBMC PBG
E358  2 TBI  30 74  86  5.7  30  55  
E360  2 TBI  53  60 232  1.5  52  64  
E367  1 TBI  68  88  414 7.1  60  90  
E390  2 TBI  58  81  100  8.0 63  80  
E392  2 TBI  35  56  99  7.2  50 55  
E399  4.5 LNI  4  5  176  9.2  5  
E433  2 TBI  70  90  112  20.0  70  88 
E501  2 TBI  34  46  35  9.8  45  50 
Dog Conditioning (Gy)% Donor chimerism before DLI Day of DLICD3+ cells infused (×107/kg) % Donor chimerism after DLI*
PBMC PBG PBMC PBG
E358  2 TBI  30 74  86  5.7  30  55  
E360  2 TBI  53  60 232  1.5  52  64  
E367  1 TBI  68  88  414 7.1  60  90  
E390  2 TBI  58  81  100  8.0 63  80  
E392  2 TBI  35  56  99  7.2  50 55  
E399  4.5 LNI  4  5  176  9.2  5  
E433  2 TBI  70  90  112  20.0  70  88 
E501  2 TBI  34  46  35  9.8  45  50 

PBMC indicates peripheral blood mononuclear cells; PBG, peripheral blood granulocytes; TBI, total-body irradiation; and LNI, lymph node irradiation.

*

Determined 16 to 20 weeks after unmodified DLI, except in dog E367, in which it was determined 10 weeks after unmodified DLI.

Day after transplantation.

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