Outcome of unmodified donor lymphocyte infusion (DLI) in mixed chimeric recipients
Dog . | Conditioning (Gy) . | % Donor chimerism before DLI . | Day of DLI† . | CD3+ cells infused (×107/kg) . | % Donor chimerism after DLI* . | ||
---|---|---|---|---|---|---|---|
PBMC . | PBG . | PBMC . | PBG . | ||||
E358 | 2 TBI | 30 | 74 | 86 | 5.7 | 30 | 55 |
E360 | 2 TBI | 53 | 60 | 232 | 1.5 | 52 | 64 |
E367 | 1 TBI | 68 | 88 | 414 | 7.1 | 60 | 90 |
E390 | 2 TBI | 58 | 81 | 100 | 8.0 | 63 | 80 |
E392 | 2 TBI | 35 | 56 | 99 | 7.2 | 50 | 55 |
E399 | 4.5 LNI | 4 | 5 | 176 | 9.2 | 5 | 5 |
E433 | 2 TBI | 70 | 90 | 112 | 20.0 | 70 | 88 |
E501 | 2 TBI | 34 | 46 | 35 | 9.8 | 45 | 50 |
Dog . | Conditioning (Gy) . | % Donor chimerism before DLI . | Day of DLI† . | CD3+ cells infused (×107/kg) . | % Donor chimerism after DLI* . | ||
---|---|---|---|---|---|---|---|
PBMC . | PBG . | PBMC . | PBG . | ||||
E358 | 2 TBI | 30 | 74 | 86 | 5.7 | 30 | 55 |
E360 | 2 TBI | 53 | 60 | 232 | 1.5 | 52 | 64 |
E367 | 1 TBI | 68 | 88 | 414 | 7.1 | 60 | 90 |
E390 | 2 TBI | 58 | 81 | 100 | 8.0 | 63 | 80 |
E392 | 2 TBI | 35 | 56 | 99 | 7.2 | 50 | 55 |
E399 | 4.5 LNI | 4 | 5 | 176 | 9.2 | 5 | 5 |
E433 | 2 TBI | 70 | 90 | 112 | 20.0 | 70 | 88 |
E501 | 2 TBI | 34 | 46 | 35 | 9.8 | 45 | 50 |
PBMC indicates peripheral blood mononuclear cells; PBG, peripheral blood granulocytes; TBI, total-body irradiation; and LNI, lymph node irradiation.
Determined 16 to 20 weeks after unmodified DLI, except in dog E367, in which it was determined 10 weeks after unmodified DLI.
Day after transplantation.