Motif and individual ligands of HLA-A2 molecules isolated from platelets
| . | Position . | Protein Source . | Accession N° EMBL Database . | Number of Times Found . | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 . | 2 . | 3 . | 4 . | 5 . | 6 . | 7 . | 8 . | 9 . | . | ||||
| Anchors or auxiliary anchors | L | L | |||||||||||
| V | |||||||||||||
| Preferred residues | I | M | I | E | F | ||||||||
| P | D | ||||||||||||
| P | |||||||||||||
| Ligands | I | L | M | E | H | H | K | L | 60S Ribosomal protein L19 (137-145) | X63527 | 1 | ||
| L | L | I | E | N | V | A | S | L | Gluthatione peroxidase (38-46) | Y00483 | 1 | ||
| L | I | E | N | V | A | S | L | Gluthatione Peroxidase (39-46) | Y00483 | 1 | |||
| X | L | I | D | F | A | L | Y | L | unknown | 1 | |||
| A | L | S | N | L | E | V | K | L | unknown | 1 | |||
| I | L | F | G | H | E | N | R | V | β5-Guanine nucleotide binding (320-329) | AF017656 | 2 | ||
| I | L | D | Q | K | N | E | V | Ornithine decarboxylase (23-31) | M31061 | 1 | |||
| S | L | A | G | G | I | G | V | Ribonucleoprotein K (154-162) | S74678 | 1 | |||
| Y | L | L | P | A | V | H | I | p68 RNA helicase (148-156) | X52104 | 2 | |||
| X | L | P | D | F | G | I | S | Y | V | unknown | 2 | ||
| A | L | N | E | L | L | Q | H | V | mouse Talin (777-785) | X56123 | 1 | ||
| F | L | L | W | A | T | A | E | A | GPIX glycoprotein (8-16) | X52997 | 3 | ||
| Other peptides found | K K R E E A P S L | Fibrinogen β-chain (51-59) | J00129 | 1 | |||||||||
| L E R P G G N E I | Fibrinogen α-chain (261-269) | M64982 | 1 | ||||||||||
| S G S F R P D S P G S … | Fibrinogen α-chain (390-…) | M64982 | 1 | ||||||||||
| . | Position . | Protein Source . | Accession N° EMBL Database . | Number of Times Found . | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 . | 2 . | 3 . | 4 . | 5 . | 6 . | 7 . | 8 . | 9 . | . | ||||
| Anchors or auxiliary anchors | L | L | |||||||||||
| V | |||||||||||||
| Preferred residues | I | M | I | E | F | ||||||||
| P | D | ||||||||||||
| P | |||||||||||||
| Ligands | I | L | M | E | H | H | K | L | 60S Ribosomal protein L19 (137-145) | X63527 | 1 | ||
| L | L | I | E | N | V | A | S | L | Gluthatione peroxidase (38-46) | Y00483 | 1 | ||
| L | I | E | N | V | A | S | L | Gluthatione Peroxidase (39-46) | Y00483 | 1 | |||
| X | L | I | D | F | A | L | Y | L | unknown | 1 | |||
| A | L | S | N | L | E | V | K | L | unknown | 1 | |||
| I | L | F | G | H | E | N | R | V | β5-Guanine nucleotide binding (320-329) | AF017656 | 2 | ||
| I | L | D | Q | K | N | E | V | Ornithine decarboxylase (23-31) | M31061 | 1 | |||
| S | L | A | G | G | I | G | V | Ribonucleoprotein K (154-162) | S74678 | 1 | |||
| Y | L | L | P | A | V | H | I | p68 RNA helicase (148-156) | X52104 | 2 | |||
| X | L | P | D | F | G | I | S | Y | V | unknown | 2 | ||
| A | L | N | E | L | L | Q | H | V | mouse Talin (777-785) | X56123 | 1 | ||
| F | L | L | W | A | T | A | E | A | GPIX glycoprotein (8-16) | X52997 | 3 | ||
| Other peptides found | K K R E E A P S L | Fibrinogen β-chain (51-59) | J00129 | 1 | |||||||||
| L E R P G G N E I | Fibrinogen α-chain (261-269) | M64982 | 1 | ||||||||||
| S G S F R P D S P G S … | Fibrinogen α-chain (390-…) | M64982 | 1 | ||||||||||
Classification of anchor residues (bold symbols), auxiliary anchor residues (underlined symbols), preferred residues, and identification of individual ligands were carried out as described in Materials and methods. Results are combined from 4 independent experiments. Amino acids are coded by their one-letter symbols. X indicates unidentified.