Sequence similarities to myelomonocytic and activation-specific cis-acting sites in 1 kilobase of genomic DNA upstream of MEFV
| Putative cis-acting Site . | Location . |
|---|---|
| Sites common in myeloid-specific promoters | |
| C/EBPα | −57 |
| PU.1 | −77, −320 |
| AML | −247 |
| TAL1 | −260 |
| c-myb | −403 |
| Sites required for cytokine activation | |
| Interferon-stimulated response element | −105 |
| Nuclear factor κB | −164 |
| Interferon regulatory factor 2 | −469 |
| Interferon γ-activation sequence | −731 |
| Putative cis-acting Site . | Location . |
|---|---|
| Sites common in myeloid-specific promoters | |
| C/EBPα | −57 |
| PU.1 | −77, −320 |
| AML | −247 |
| TAL1 | −260 |
| c-myb | −403 |
| Sites required for cytokine activation | |
| Interferon-stimulated response element | −105 |
| Nuclear factor κB | −164 |
| Interferon regulatory factor 2 | −469 |
| Interferon γ-activation sequence | −731 |
The MEFV promoter region (AF111163) was screened for transcription factor binding sites in the TRANSFAC database by using MatInspector software. Locations are listed relative to the transcription start site defined by 5′ RACE,1 which is 41 base pairs upstream of the ATG initiation codon.