Sensitivity of quality adjusted life years for intention to transplant versus intention to transfuse to changes in model assumptions
| Variable . | Baseline value . | Range . | Intention to transplant (QALYs range) . | Intention to transfuse (QALYs range) . |
|---|---|---|---|---|
| Discount rate | 0.03 | 0-0.10 | 6.8-27.8 | 6.8-26.8 |
| Age at transplantation | 5 y | 2-10 y | 15.0-15.3 | 14.7-15.0 |
| PBT | ||||
| Duration | Lifetime | 3 y-lifetime | 15.2-16.6 | 14.9-16.5 |
| Relative risk of death6-150 | 0.40 | 0.30-0.50 | 15.1-15.4 | 14.8-15.1 |
| Noncompliance with transfusion regimen | 0.20 | 0-0.50 | 15.0-15.4 | 14.7-15.1 |
| Noncompliance with iron chelation | 0.65 | 0-0.80 | 14.8-17.1 | 14.5-17.0 |
| Refusal | 0.20 | 0.05-0.25 | 15.1-15.7 | 14.8-15.5 |
| BMT | ||||
| Donor available | 0.14 | 0.10-0.30 | 15.2-15.6 | 14.9-14.9 |
| Refusal, excluded | 0.43 | 0.20-0.60 | 15.1-15.3 | 14.9-14.9 |
| 1-y mortality risk | 0.06 | 0.03-0.12 | 15.1-15.3 | 14.9-14.9 |
| Variable . | Baseline value . | Range . | Intention to transplant (QALYs range) . | Intention to transfuse (QALYs range) . |
|---|---|---|---|---|
| Discount rate | 0.03 | 0-0.10 | 6.8-27.8 | 6.8-26.8 |
| Age at transplantation | 5 y | 2-10 y | 15.0-15.3 | 14.7-15.0 |
| PBT | ||||
| Duration | Lifetime | 3 y-lifetime | 15.2-16.6 | 14.9-16.5 |
| Relative risk of death6-150 | 0.40 | 0.30-0.50 | 15.1-15.4 | 14.8-15.1 |
| Noncompliance with transfusion regimen | 0.20 | 0-0.50 | 15.0-15.4 | 14.7-15.1 |
| Noncompliance with iron chelation | 0.65 | 0-0.80 | 14.8-17.1 | 14.5-17.0 |
| Refusal | 0.20 | 0.05-0.25 | 15.1-15.7 | 14.8-15.5 |
| BMT | ||||
| Donor available | 0.14 | 0.10-0.30 | 15.2-15.6 | 14.9-14.9 |
| Refusal, excluded | 0.43 | 0.20-0.60 | 15.1-15.3 | 14.9-14.9 |
| 1-y mortality risk | 0.06 | 0.03-0.12 | 15.1-15.3 | 14.9-14.9 |
QALYs = quality-adjusted life years; PBT = periodic blood transfusion; BMT = bone marrow transplantation.
Relative to typical SCD patients.