Table 2. Summary of metabolic inhibitors... | American Society of Hematology

Table 2.

Summary of metabolic inhibitors used during the platelet pulsing

Cytokine/Inhibitor	Biochemical Effect	Ref
IFN-γ	Up-regulates nitric oxide production	41, 42
	Up-regulates MHC class II expression and iNOS	32
Aminoguanidine	Inhibits iNOS production of NO	43, 44
L-arginine	Amino acid substrate for iNOS.	43, 44
Colchicine	Inhibits tubulin polymerization	31
NH₄Cl	Prevents endosomal/lysosomal acidification	45
Chloroquine	Prevents endosomal/lysosomal acidification	46, 47
	Strips β₂M from MHC class I	27, 28
Brefeldin A	Inhibits nascent protein transport from E/R to golgi.	48
MG115	Inhibits cytosolic proteasomes	49

Cytokine/Inhibitor	Biochemical Effect	Ref
IFN-γ	Up-regulates nitric oxide production	41, 42
	Up-regulates MHC class II expression and iNOS	32
Aminoguanidine	Inhibits iNOS production of NO	43, 44
L-arginine	Amino acid substrate for iNOS.	43, 44
Colchicine	Inhibits tubulin polymerization	31
NH₄Cl	Prevents endosomal/lysosomal acidification	45
Chloroquine	Prevents endosomal/lysosomal acidification	46, 47
	Strips β₂M from MHC class I	27, 28
Brefeldin A	Inhibits nascent protein transport from E/R to golgi.	48
MG115	Inhibits cytosolic proteasomes	49