Results of study
| Patient . | Age . | Sex . | Related Disease . | HIV Status . | Diagnosis and Sites of Disease . | Site of Biopsy Tested . | Plasmablasts . | HHV-8 LNA . | Plasmablasts Light-Chain Restriction . | Microscopic Lymphoma . | Clinical Outcome . |
|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | 32 | M | KS, skin | + | MCD PC LNs, spleen | Spleen | + | + | Lambda | Yes | Died 6 months after the diagnosis of CD owing to a blast crisis where leukocyte count was 38 000 with 85% “immunoblasts” |
| 2 | 62 | M | + | MCD PC LNs, spleen | Lymph node Spleen | + + | + + | Lambda Lambda | No Yes | Died 7 months after the diagnosis of CD owing to disease progression and ketoacidosis | |
| 3 | 46 | M | + | MCD PC LNs, spleen Lymphoma | Lymph node Spleen Muscle | + + + | + + + | Lambda Lambda U | No No — | 9 months after a splenectomy for CD, developed plasmablastic lymphoma and died 10 months later owing to PD | |
| 4 | 47 | F | KS, skin & palate | + | MCD PC LNs, spleen Lymphoma | Lymph node Spleen Pharynx | + + + | + + + | Lambda Lambda Lambda | No Yes — | Died 9 months after the diagnosis of CD with pancytopenia and PD. Also had plasmablastic lymphoma in pharynx |
| 5 | 60 | M | KS, skin | + | MCD PC LNs Lymphoma | Lymph node Lymph node | + + | + + | Lambda Lambda | No — | Died within weeks after the diagnosis of lymphoma, cause unknown |
| 6 | 35 | M | KS, skin and LNs | + | MCD PC LNs | Lymph node | + | + | Lambda | No | Lost to follow-up |
| 7 | 40 | M | + | MCD PC LNs | Lymph node | + | + | Lambda | No | Died 9 months after the diagnosis of CD, owing to progressive AIDS | |
| 8 | 37 | M | KS, LN | + | MCD PC LNs | Lymph node | + | + | Lambda | No | Alive |
| 9 | 32 | M | PEL | − | MCD PC LNs | Lymph node | + | + | Lambda | No | Alive |
| 10 | 73 | F | − | MCD PC LNs | Lymph node | + | + | Lambda | No | Alive, but progressive CD | |
| 11 | 43 | F | − | LCD HV | Lymph node | − | − | No | No | Alive | |
| 12 | 48 | M | − | LCD HV | Lymph node | − | − | No | No | Lost to follow-up | |
| 13 | 31 | F | − | MCD PC LNs | Lymph node | − | − | No | No | Alive | |
| 14 | 64 | F | − | LCD HV | Lymph node | − | − | No | No | Alive for more than 10 years | |
| 15 | ? | M | − | LCD HV | Lymph node | − | − | No | No | Lost to follow-up | |
| 16 | 19 | F | − | LCD HV | Lymph node | − | − | No | No | Alive | |
| 17 | 16 | M | − | LCD HV | Lymph node | − | − | No | No | Alive | |
| 18 | 65 | M | − | MCD PC LNs | Lymph node | − | − | No | No | Alive | |
| 19 | 45 | M | − | MCD PC LNs | Lymph node | − | − | No | No | Alive | |
| 20 | 44 | F | − | LCD HV | Lymph node | − | − | No | No | Alive |
| Patient . | Age . | Sex . | Related Disease . | HIV Status . | Diagnosis and Sites of Disease . | Site of Biopsy Tested . | Plasmablasts . | HHV-8 LNA . | Plasmablasts Light-Chain Restriction . | Microscopic Lymphoma . | Clinical Outcome . |
|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | 32 | M | KS, skin | + | MCD PC LNs, spleen | Spleen | + | + | Lambda | Yes | Died 6 months after the diagnosis of CD owing to a blast crisis where leukocyte count was 38 000 with 85% “immunoblasts” |
| 2 | 62 | M | + | MCD PC LNs, spleen | Lymph node Spleen | + + | + + | Lambda Lambda | No Yes | Died 7 months after the diagnosis of CD owing to disease progression and ketoacidosis | |
| 3 | 46 | M | + | MCD PC LNs, spleen Lymphoma | Lymph node Spleen Muscle | + + + | + + + | Lambda Lambda U | No No — | 9 months after a splenectomy for CD, developed plasmablastic lymphoma and died 10 months later owing to PD | |
| 4 | 47 | F | KS, skin & palate | + | MCD PC LNs, spleen Lymphoma | Lymph node Spleen Pharynx | + + + | + + + | Lambda Lambda Lambda | No Yes — | Died 9 months after the diagnosis of CD with pancytopenia and PD. Also had plasmablastic lymphoma in pharynx |
| 5 | 60 | M | KS, skin | + | MCD PC LNs Lymphoma | Lymph node Lymph node | + + | + + | Lambda Lambda | No — | Died within weeks after the diagnosis of lymphoma, cause unknown |
| 6 | 35 | M | KS, skin and LNs | + | MCD PC LNs | Lymph node | + | + | Lambda | No | Lost to follow-up |
| 7 | 40 | M | + | MCD PC LNs | Lymph node | + | + | Lambda | No | Died 9 months after the diagnosis of CD, owing to progressive AIDS | |
| 8 | 37 | M | KS, LN | + | MCD PC LNs | Lymph node | + | + | Lambda | No | Alive |
| 9 | 32 | M | PEL | − | MCD PC LNs | Lymph node | + | + | Lambda | No | Alive |
| 10 | 73 | F | − | MCD PC LNs | Lymph node | + | + | Lambda | No | Alive, but progressive CD | |
| 11 | 43 | F | − | LCD HV | Lymph node | − | − | No | No | Alive | |
| 12 | 48 | M | − | LCD HV | Lymph node | − | − | No | No | Lost to follow-up | |
| 13 | 31 | F | − | MCD PC LNs | Lymph node | − | − | No | No | Alive | |
| 14 | 64 | F | − | LCD HV | Lymph node | − | − | No | No | Alive for more than 10 years | |
| 15 | ? | M | − | LCD HV | Lymph node | − | − | No | No | Lost to follow-up | |
| 16 | 19 | F | − | LCD HV | Lymph node | − | − | No | No | Alive | |
| 17 | 16 | M | − | LCD HV | Lymph node | − | − | No | No | Alive | |
| 18 | 65 | M | − | MCD PC LNs | Lymph node | − | − | No | No | Alive | |
| 19 | 45 | M | − | MCD PC LNs | Lymph node | − | − | No | No | Alive | |
| 20 | 44 | F | − | LCD HV | Lymph node | − | − | No | No | Alive |
HIV indicates human immunodeficiency virus; HHV-8 LNA, human herpesvirus 8 latent nuclear antigen; KS, Kaposi's sarcoma; MCD PC, multicentric Castleman disease, plasma cell type; LNs, lymph nodes; CD, Castleman disease; U, unsatisfactory staining; PD, progressive disease; LCD HV, localized Castleman disease, hyalin vascular type; PEL, primary effusion lymphoma.