Distribution of GSTM1, GSTT1, GSTP1 genotypes and their association with the occurrence of relapse in 64 case subjects and 64 successfully treated matched control subjects with acute lymphoblastic leukemia from ALL-BFM trials 86 and 90
| . | No. of Subjects and Prevalence (%) . | OR (95% CI) . | P Value . | |
|---|---|---|---|---|
| Cases . | Controls . | |||
| GSTMI | ||||
| Present | 37 (57.8) | 27 (42.2) | 1.004-150 | |
| Null | 27 (42.2) | 37 (57.8) | 0.50 (0.23-1.07) | .078 |
| GSTT1 | ||||
| Present | 59 (92.2) | 50 (78.1) | 1.004-150 | |
| Null | 5 (7.8) | 14 (21.9) | 0.36 (0.13-0.99) | .048 |
| GSTP1 codon 105 | ||||
| Ile/Ile | 33 (51.6) | 32 (50.0) | ||
| Ile/Val | 27 (42.2) | 22 (34.4) | 1.004-151 | |
| Val/Val | 4 (6.3) | 10 (15.6) | 0.33 (0.09-1.23) | .099 |
| GSTP1 codon 114 | ||||
| Ala/Ala | 52 (81.3) | 48 (75.0) | 1.004-150 | |
| Ala/Val | 11 (17.2) | 16 (25.0) | 0.85‡ (0.38-1.88) | .682 |
| Val/Val | 1 (1.6) | — | ||
| . | No. of Subjects and Prevalence (%) . | OR (95% CI) . | P Value . | |
|---|---|---|---|---|
| Cases . | Controls . | |||
| GSTMI | ||||
| Present | 37 (57.8) | 27 (42.2) | 1.004-150 | |
| Null | 27 (42.2) | 37 (57.8) | 0.50 (0.23-1.07) | .078 |
| GSTT1 | ||||
| Present | 59 (92.2) | 50 (78.1) | 1.004-150 | |
| Null | 5 (7.8) | 14 (21.9) | 0.36 (0.13-0.99) | .048 |
| GSTP1 codon 105 | ||||
| Ile/Ile | 33 (51.6) | 32 (50.0) | ||
| Ile/Val | 27 (42.2) | 22 (34.4) | 1.004-151 | |
| Val/Val | 4 (6.3) | 10 (15.6) | 0.33 (0.09-1.23) | .099 |
| GSTP1 codon 114 | ||||
| Ala/Ala | 52 (81.3) | 48 (75.0) | 1.004-150 | |
| Ala/Val | 11 (17.2) | 16 (25.0) | 0.85‡ (0.38-1.88) | .682 |
| Val/Val | 1 (1.6) | — | ||
Reference category.
Reference category was a combined category of Ile105/Ile105 and Ile105/Val105 genotypes, because OR for Ile105/Val105 compared with Ile105/Ile105 showed equal risk in both categories.
OR for the combined category of Ala114/Val114 and Val114/Val114 genotypes with reference to the Ala114/Ala114 category.
OR: Odds ratio; CI: confidence interval.