Immunophenotype of CD8+ PBMC after repetitive stimulation with idiotype-presenting dendritic cells
| Stimulation . | Patient 1 . | Patient 2 . | ||||
|---|---|---|---|---|---|---|
| DC/Fab (%) . | DC/Fd (%) . | DC/IgL (%) . | DC/Fab (%) . | DC/Fd (%) . | DC/IgL (%) . | |
| CD3+ | 77.7 | 70.1 | 66.7 | 84.3 | 90.5 | 90.8 |
| CD4+ | 40.0 | 7.4 | 9.4 | 35.9 | 5.0 | 6.1 |
| CD8+ | 67.4 | 69.9 | 55.8 | 89.9 | 92.5 | 92.1 |
| CD8+/CD4+ | 22.0 | 3.2 | 4.0 | 27.5 | 2.7 | 2.1 |
| CD8+/CD4− | 36.3 | 62.8 | 41.6 | 60.3 | 87.7 | 87.6 |
| CD4+/CD8− | 6.7 | 4.7 | 7.3 | 2.4 | 2.2 | 2.9 |
| CD3+/HLA-DR+ | 55.0 | 40.5 | 26.0 | 75.7 | 82.6 | 81.1 |
| CD56+ or CD16+ | 6.9 | 25.0 | 28.2 | 4.3 | 44.3 | 34.8 |
| γ/δ-TCR+ | 1.3 | 1.1 | 1.2 | 0.3 | 0.6 | 0.4 |
| Stimulation . | Patient 1 . | Patient 2 . | ||||
|---|---|---|---|---|---|---|
| DC/Fab (%) . | DC/Fd (%) . | DC/IgL (%) . | DC/Fab (%) . | DC/Fd (%) . | DC/IgL (%) . | |
| CD3+ | 77.7 | 70.1 | 66.7 | 84.3 | 90.5 | 90.8 |
| CD4+ | 40.0 | 7.4 | 9.4 | 35.9 | 5.0 | 6.1 |
| CD8+ | 67.4 | 69.9 | 55.8 | 89.9 | 92.5 | 92.1 |
| CD8+/CD4+ | 22.0 | 3.2 | 4.0 | 27.5 | 2.7 | 2.1 |
| CD8+/CD4− | 36.3 | 62.8 | 41.6 | 60.3 | 87.7 | 87.6 |
| CD4+/CD8− | 6.7 | 4.7 | 7.3 | 2.4 | 2.2 | 2.9 |
| CD3+/HLA-DR+ | 55.0 | 40.5 | 26.0 | 75.7 | 82.6 | 81.1 |
| CD56+ or CD16+ | 6.9 | 25.0 | 28.2 | 4.3 | 44.3 | 34.8 |
| γ/δ-TCR+ | 1.3 | 1.1 | 1.2 | 0.3 | 0.6 | 0.4 |
DC/Fab, idiotype-loaded DC; DC/Fd, DC/IgL, idiotype heavy- or light chain-transduced DC.