Survival, according to risk factors, in all patients and in patients with primary MDS
Risk Factor . | All Patients (n = 50) . | Patients with Primary MDS (n = 42) . | ||
---|---|---|---|---|
Patients Surviving/ Total No. of Patients . | KM Estimate of RFS at 3 y . | Patients Surviving/ Total No. of Patients at Risk . | KM Estimate of RFS at 3 y . | |
Source of stem cells | ||||
HLA-identical sibling | 17/36 | 0.39 | 16/30 | 0.47 |
HLA-nonidentical relative | 0/4 | 0.00 | 0/3 | 0.00 |
Syngeneic donor | 2/4 | 0.673-150 | 2/3 | 1.003-150 |
Unrelated donor | 3/6 | 0.50 | 3/6 | 0.50 |
Etiology of MDS | ||||
Primary | 21/42 | 0.38 | — | — |
Secondary | 1/8 | 0.13 | — | — |
FAB classification | ||||
RA | 7/13 | 0.53 | 7/12 | 0.57 |
RAEB | 9/19 | 0.46 | 9/17 | 0.52 |
RAEB-T/AML | 6/16 | 0.383-150 | 5/11 | 0.453-150 |
CMML | 0/2 | 0.00 | 0/2 | 0.00 |
Cytogenetic risk3-151 | ||||
Low | 13/24 | 0.45 | 12/22 | 0.50 |
Intermediate | 5/7 | 0.71 | 5/6 | 0.83 |
High | 3/15 | 0.213-150 | 3/11 | 0.303-150 |
IPSS3-152 | ||||
Low (0) | 1/2 | 0.50 | 1/1 | 1.00 |
Intermediate 1 (0.5-1) | 7/14 | 0.50 | 7/13 | 0.54 |
Intermediate 2 (1.5-2.0) | 10/19 | 0.41 | 10/18 | 0.44 |
High (>2.5) | 3/10 | 0.273-150 | 2/6 | 0.503-150 |
Risk Factor . | All Patients (n = 50) . | Patients with Primary MDS (n = 42) . | ||
---|---|---|---|---|
Patients Surviving/ Total No. of Patients . | KM Estimate of RFS at 3 y . | Patients Surviving/ Total No. of Patients at Risk . | KM Estimate of RFS at 3 y . | |
Source of stem cells | ||||
HLA-identical sibling | 17/36 | 0.39 | 16/30 | 0.47 |
HLA-nonidentical relative | 0/4 | 0.00 | 0/3 | 0.00 |
Syngeneic donor | 2/4 | 0.673-150 | 2/3 | 1.003-150 |
Unrelated donor | 3/6 | 0.50 | 3/6 | 0.50 |
Etiology of MDS | ||||
Primary | 21/42 | 0.38 | — | — |
Secondary | 1/8 | 0.13 | — | — |
FAB classification | ||||
RA | 7/13 | 0.53 | 7/12 | 0.57 |
RAEB | 9/19 | 0.46 | 9/17 | 0.52 |
RAEB-T/AML | 6/16 | 0.383-150 | 5/11 | 0.453-150 |
CMML | 0/2 | 0.00 | 0/2 | 0.00 |
Cytogenetic risk3-151 | ||||
Low | 13/24 | 0.45 | 12/22 | 0.50 |
Intermediate | 5/7 | 0.71 | 5/6 | 0.83 |
High | 3/15 | 0.213-150 | 3/11 | 0.303-150 |
IPSS3-152 | ||||
Low (0) | 1/2 | 0.50 | 1/1 | 1.00 |
Intermediate 1 (0.5-1) | 7/14 | 0.50 | 7/13 | 0.54 |
Intermediate 2 (1.5-2.0) | 10/19 | 0.41 | 10/18 | 0.44 |
High (>2.5) | 3/10 | 0.273-150 | 2/6 | 0.503-150 |