Table 2. Multivariate analysis of risk... | American Society of Hematology

Table 2.

Multivariate analysis of risk factors associated with t-MDS/t-AML (cohort study)

Risk Factors	Total Cohort (n = 612) Relative Risk (95% CI^*)	Hodgkin's Disease (n = 218) Relative Risk (95% CI^*)	Non-Hodgkin's Lymphoma (n = 394) Relative Risk (95% CI^*)
Age at transplant
<40 y	1.0	1.0	1.0
≥40 y	1.1 (0.5-2.6)	1.1 (0.2-5.2)	2.2 (0.6-8.1)
Gender
Males	1.0	1.0	1.0
Females	2.2 (0.9-5.3)	2.4 (0.6-9.2)	1.8 (0.6-5.9)
Primary diagnosis
NHL^¶	1.0
HD^†	1.6 (0.6-3.7)	—	—
Source of stem cells
BM	1.0	1.0	1.0
PSC/BM + PSC^‡	0.9 (0.3-3.0)	0.8 (0.2-3.8)	1.0 (0.1-8.1)
Priming with VP-16
No	1.0	1.0	1.0
Yes	7.7 (2.1-28.7)^†	8.3 (1.6-43.9)^†	5.9 (0.6-57.1)

Risk Factors	Total Cohort (n = 612) Relative Risk (95% CI^*)	Hodgkin's Disease (n = 218) Relative Risk (95% CI^*)	Non-Hodgkin's Lymphoma (n = 394) Relative Risk (95% CI^*)
Age at transplant
<40 y	1.0	1.0	1.0
≥40 y	1.1 (0.5-2.6)	1.1 (0.2-5.2)	2.2 (0.6-8.1)
Gender
Males	1.0	1.0	1.0
Females	2.2 (0.9-5.3)	2.4 (0.6-9.2)	1.8 (0.6-5.9)
Primary diagnosis
NHL^¶	1.0
HD^†	1.6 (0.6-3.7)	—	—
Source of stem cells
BM	1.0	1.0	1.0
PSC/BM + PSC^‡	0.9 (0.3-3.0)	0.8 (0.2-3.8)	1.0 (0.1-8.1)
Priming with VP-16
No	1.0	1.0	1.0
Yes	7.7 (2.1-28.7)^†	8.3 (1.6-43.9)^†	5.9 (0.6-57.1)

95% CI denotes 95% confidence interval.

†

P < 0.05.

BM indicates bone marrow alone as the source of stem cells; HD, Hodgkin's disease; NHL, non-Hodgkin's lymphoma; PSC/BM + PSC, peripheral stem cells or bone marrow and peripheral stem cells as the source of stem cells.

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