Table 5.

Risk factors in Cys282Tyr homozygotes with PCT compared to Cys282Tyr homozygotes without PCT

With PCT Without PCT Odds Ratio 95% CLs
Alcohol  10/16* 15/57  4.7  1.5-14.4  
HCV+  6/14 3/60  14.3  3.7-54.6  
Estrogen  6/7  9/27  12.0 1.6-87.6 
With PCT Without PCT Odds Ratio 95% CLs
Alcohol  10/16* 15/57  4.7  1.5-14.4  
HCV+  6/14 3/60  14.3  3.7-54.6  
Estrogen  6/7  9/27  12.0 1.6-87.6 

Cys282Tyr homozygote controls without PCT were matched by sex and age (±5 years). All controls were adults. (One female with PCT was a prepuberal 12-year-old girl, and 3 Cys282Tyr homozygotes with PCT were children. They are not included here.) We matched 3 nonporphyric homozygotes for each homozygote with PCT. The alcohol study includes all subjects consuming more than 20 g of alcohol daily.

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