Summary of clinical laboratory and markers of hemostatic and inflammatory system responses to sublethal Escherichia coli plus blocking or nonblocking mAb to EPCR, or saline
| Measurements . | Blocking Anti-EPCR mAb Plus SLEC . | Nonblocking Anti-EPCR mAb Plus SLEC . | Saline Plus SLEC . | ||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| T-0 . | 2 h . | 4 h . | 6 h . | 24 h . | T-0 . | 2 h . | 4 h . | 6 h . | 24 h . | T-0 . | 2 h . | 4 h . | 6 h . | 24 hr . | |
| Temperature (R) (°C) | 7.3 ± 0.2 | 8.4 ± 0.3 | 38.1 ± 0.5 | 38.1 ± 0.3 | 38.9 ± 0.1 | 6.8 ± 0.2 | 7.5 ± 0.4 | 38 ± 0.3 | 7.9 ± 0.2 | 9.2 ± 0.3 | 6.8 ± 0.2 | 37 ± 0.2 | 7.9 ± 0.2 | 37.9 ± 0.2 | 37.9 ± 0.2 |
| t-PA (ng/mL) | .7 ± 0.6 | 131.8 ± 13.2 | 17.5 ± 14.7 | 164 ± 35.7 | 19.5 ± 22.1 | 3.1 ± 1.6 | 118.8 ± 15.0 | 91.2 ± 12.3 | 103.1 ± 20.1 | 3.7 ± 8.2 | .3 ± 0.5 | 79.4 ± 13.9 | 4.6 ± 59.1 | 4.5 ± 12.9 | 33.9 ± 18.7 |
| Platelets ×106/nm3 | 206.2 ± 28.9 | 159.7 ± 26.2 | 135 ± 9.1 | 14.7 ± 16.5 | 80.5 ± 7.5 | 365.3 ± 44.6 | 277.3 ± 25.9 | 242 ± 10.6 | 91.33 ± 3.5 | 9.7 ± 2.3 | 306.2 ± 20.1 | 223.3 ± 14.7 | 215.2 ± 26.4 | 66.7 ± 13.1 | 84.4 ± 9.5 |
| WBC ×103/mm3 | .5 ± 1.7 | 1.3 ± 0.3 | 1.7 ± 0.2 | 2.7 ± 0.6 | 6.8 ± 0.5 | 3.8 ± 0.3 | 0.9 ± 0.2 | .6 ± 0.4 | 2 ± 0.5 | .8 ± 2.1 | .1 ± 0.8 | .7 ± 0.4 | 5 ± 2 | 4.7 ± 0.9 | 15.3 ± 2.3 |
| Elastase | 0.7 ± 0 | 3.4 ± 0.5 | 4.3 ± 0.3 | 5.6 ± 0.5 | 4.0 ± 0.6 | 0.8 ± 0.3 | 3.0 ± 0.5 | 4.1 ± 0.4 | 4.9 ± 0.5 | 3.4 ± 0.5 | — | — | — | — | — |
| TNF (ng/mL) | <5 ± 0 | 4.5 ± 4.4 | <5 ± 0 | <5 ± 0 | <5 ± 0 | <5 ± 0 | 4.4 ± 12.3 | 5 ± 0 | 5 ± 0 | 5 ± 0 | 7.9 ± 1 | 1.1 ± 9.6 | 8.3 ± 1.7 | 10 ± 2 | 8.2 ± 1.1 |
| Creatinine (mg/dL) | .6 ± 0.1 | — | 1.1 ± 0.3 | 1.9 | 4.3 ± 1 | 0.5 ± 0.1 | — | — | — | .6 ± 0.1 | .6 ± 0.1 | — | — | 0.7 ± 0.1 | 1.5 ± 0.6 |
| Anion Gap | 12.3 ± 1.8 | — | 14.5 ± 1.5 | 24 | 22.3 ± 2.6 | 11 | — | — | — | 12 | 12.8 ± 1.2 | — | — | 15.7 ± 1.1 | 15.3 ± 1.3 |
| SGPT/ALT (u/L) | 53.8 ± 9.3 | — | 52 ± 10 | 91 | 492.3 ± 129.5 | 72 ± 19 | — | — | — | 184.5 ± 93.8 | 59.4 ± 10.1 | — | — | 4.8 ± 19.3 | 97.3 ± 93.4 |
| Measurements . | Blocking Anti-EPCR mAb Plus SLEC . | Nonblocking Anti-EPCR mAb Plus SLEC . | Saline Plus SLEC . | ||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| T-0 . | 2 h . | 4 h . | 6 h . | 24 h . | T-0 . | 2 h . | 4 h . | 6 h . | 24 h . | T-0 . | 2 h . | 4 h . | 6 h . | 24 hr . | |
| Temperature (R) (°C) | 7.3 ± 0.2 | 8.4 ± 0.3 | 38.1 ± 0.5 | 38.1 ± 0.3 | 38.9 ± 0.1 | 6.8 ± 0.2 | 7.5 ± 0.4 | 38 ± 0.3 | 7.9 ± 0.2 | 9.2 ± 0.3 | 6.8 ± 0.2 | 37 ± 0.2 | 7.9 ± 0.2 | 37.9 ± 0.2 | 37.9 ± 0.2 |
| t-PA (ng/mL) | .7 ± 0.6 | 131.8 ± 13.2 | 17.5 ± 14.7 | 164 ± 35.7 | 19.5 ± 22.1 | 3.1 ± 1.6 | 118.8 ± 15.0 | 91.2 ± 12.3 | 103.1 ± 20.1 | 3.7 ± 8.2 | .3 ± 0.5 | 79.4 ± 13.9 | 4.6 ± 59.1 | 4.5 ± 12.9 | 33.9 ± 18.7 |
| Platelets ×106/nm3 | 206.2 ± 28.9 | 159.7 ± 26.2 | 135 ± 9.1 | 14.7 ± 16.5 | 80.5 ± 7.5 | 365.3 ± 44.6 | 277.3 ± 25.9 | 242 ± 10.6 | 91.33 ± 3.5 | 9.7 ± 2.3 | 306.2 ± 20.1 | 223.3 ± 14.7 | 215.2 ± 26.4 | 66.7 ± 13.1 | 84.4 ± 9.5 |
| WBC ×103/mm3 | .5 ± 1.7 | 1.3 ± 0.3 | 1.7 ± 0.2 | 2.7 ± 0.6 | 6.8 ± 0.5 | 3.8 ± 0.3 | 0.9 ± 0.2 | .6 ± 0.4 | 2 ± 0.5 | .8 ± 2.1 | .1 ± 0.8 | .7 ± 0.4 | 5 ± 2 | 4.7 ± 0.9 | 15.3 ± 2.3 |
| Elastase | 0.7 ± 0 | 3.4 ± 0.5 | 4.3 ± 0.3 | 5.6 ± 0.5 | 4.0 ± 0.6 | 0.8 ± 0.3 | 3.0 ± 0.5 | 4.1 ± 0.4 | 4.9 ± 0.5 | 3.4 ± 0.5 | — | — | — | — | — |
| TNF (ng/mL) | <5 ± 0 | 4.5 ± 4.4 | <5 ± 0 | <5 ± 0 | <5 ± 0 | <5 ± 0 | 4.4 ± 12.3 | 5 ± 0 | 5 ± 0 | 5 ± 0 | 7.9 ± 1 | 1.1 ± 9.6 | 8.3 ± 1.7 | 10 ± 2 | 8.2 ± 1.1 |
| Creatinine (mg/dL) | .6 ± 0.1 | — | 1.1 ± 0.3 | 1.9 | 4.3 ± 1 | 0.5 ± 0.1 | — | — | — | .6 ± 0.1 | .6 ± 0.1 | — | — | 0.7 ± 0.1 | 1.5 ± 0.6 |
| Anion Gap | 12.3 ± 1.8 | — | 14.5 ± 1.5 | 24 | 22.3 ± 2.6 | 11 | — | — | — | 12 | 12.8 ± 1.2 | — | — | 15.7 ± 1.1 | 15.3 ± 1.3 |
| SGPT/ALT (u/L) | 53.8 ± 9.3 | — | 52 ± 10 | 91 | 492.3 ± 129.5 | 72 ± 19 | — | — | — | 184.5 ± 93.8 | 59.4 ± 10.1 | — | — | 4.8 ± 19.3 | 97.3 ± 93.4 |
EPCR = Endothelial cell protein C receptor; SLECs = SublethalE coli; WBC = white blood cell count.