Table 1.

Frequencies of association of specific centromeres in quiescent human peripheral blood cells

Centromeres PBL n-aPBM Centromeres PBG a a
A/B B/C A/CA/B/C
1/2/3  0.18  0.16 ± 0.01  0.23  0.01 0.56  1/4  0.38* 0.47* 
2/3/4  0.16 ± 0.01 0.18  0.20 ± 0.04  0.01  0.61  3/4  0.24 0.24  
3/4/6  0.15  0.20  0.15 ± 0.02  0  0.55 3/6  0.23  0.30* 
6/7/8  0.26  0.29 ± 0.06 0.22  0.05  0.49  4/6  0.21  0.16  
7/8/9 0.29 ± 0.06  0.38  0.43 ± 0.03  0.08  0.23 7/9  0.36  ND  
9/10/11  0.24  0.42  0.35 0.05  0.34  10/11  0.26* 0.24* 
10/11/12  0.42 0.37  0.26  0.06  0.29  11/12  0.22*,† 0.52*,† 
12/15/16  0.24  0.46 ± 0.02  0.20  0.05  0.21 13/21  0.82* 0.70  
15/16/17  0.46 ± 0.02 0.25 ± 0.02  0.35 ± 0.03  0.07  0.24  14/22 0.79  ND  
17/18/20  0.34  0.41  0.21 0.07  0.22  15/16  0.44  0.34  
20/X/Y  0.22 0.13  0.09  0.01  0.60  18/20  0.56* ND 
Y/1/2  0.16  0.19  0.10  0  0.57  
5/19  0.23    0.77  
13/21  0.64     0.36  
14/22 0.69     0.31  
1/4  0.19     0.81 
2/6  0.18     0.82  
7/11  0.30    0.70 
Centromeres PBL n-aPBM Centromeres PBG a a
A/B B/C A/CA/B/C
1/2/3  0.18  0.16 ± 0.01  0.23  0.01 0.56  1/4  0.38* 0.47* 
2/3/4  0.16 ± 0.01 0.18  0.20 ± 0.04  0.01  0.61  3/4  0.24 0.24  
3/4/6  0.15  0.20  0.15 ± 0.02  0  0.55 3/6  0.23  0.30* 
6/7/8  0.26  0.29 ± 0.06 0.22  0.05  0.49  4/6  0.21  0.16  
7/8/9 0.29 ± 0.06  0.38  0.43 ± 0.03  0.08  0.23 7/9  0.36  ND  
9/10/11  0.24  0.42  0.35 0.05  0.34  10/11  0.26* 0.24* 
10/11/12  0.42 0.37  0.26  0.06  0.29  11/12  0.22*,† 0.52*,† 
12/15/16  0.24  0.46 ± 0.02  0.20  0.05  0.21 13/21  0.82* 0.70  
15/16/17  0.46 ± 0.02 0.25 ± 0.02  0.35 ± 0.03  0.07  0.24  14/22 0.79  ND  
17/18/20  0.34  0.41  0.21 0.07  0.22  15/16  0.44  0.34  
20/X/Y  0.22 0.13  0.09  0.01  0.60  18/20  0.56* ND 
Y/1/2  0.16  0.19  0.10  0  0.57  
5/19  0.23    0.77  
13/21  0.64     0.36  
14/22 0.69     0.31  
1/4  0.19     0.81 
2/6  0.18     0.82  
7/11  0.30    0.70 

PBL, peripheral blood lymphocytes; PBM, peripheral blood monocytes; PBG, peripheral blood granulocytes; A-B-C, triad of centromeres analyzed. A/B, B/C, A/C, A/B/C, respectively, associations between the first and the second centromere of the triad, the second and the third, the first and the third, and all three. Association between homologous centromeres is not indicated (see text). a, associated; n-a, nonassociated; ND, not done.

*

Comparison with lymphocytes, P < .05.

†

Comparison between monocytes and granulocytes, P < .05.

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