Table 2. Plasma pharmacokinetic... | American Society of Hematology

Table 2.

Plasma pharmacokinetic parameters for MPO after intravenous or subcutaneous administration to normal rhesus monkeys

Pharmacokinetic Parameters	Rhesus
Intravenous^*
Dose (μg/kg)	10
Half-lives (h)
First	0.533 ± 0.051
Second	25.3 ± 14.0
Clearance (mL/min/kg)	0.415 ± 0.070
V_C (L/kg)^†	0.0220 ± 0.0026
V_SS (L/kg)^†	0.0706 ± 0.0481
Subcutaneous^*
Dose (μg/kg)	30
C_MAX (ng/mL)	97.4 ± 29.1
T_MAX (h)	3.3 ± 1.3
AUC ([ng/mL]h)^‡	806 ± 368
Bioavailability (%)	62.5

Pharmacokinetic Parameters	Rhesus
Intravenous^*
Dose (μg/kg)	10
Half-lives (h)
First	0.533 ± 0.051
Second	25.3 ± 14.0
Clearance (mL/min/kg)	0.415 ± 0.070
V_C (L/kg)^†	0.0220 ± 0.0026
V_SS (L/kg)^†	0.0706 ± 0.0481
Subcutaneous^*
Dose (μg/kg)	30
C_MAX (ng/mL)	97.4 ± 29.1
T_MAX (h)	3.3 ± 1.3
AUC ([ng/mL]h)^‡	806 ± 368
Bioavailability (%)	62.5

Values are the mean (±SEM) for 3 monkeys.

V_C and V_SS are the apparent central compartment and steady state volumes of distribution, respectively.

Values are calculated from 0 to 24 hours for monkeys.