Comparison of radiation-induced hematologic effects: 700 cGy 60Co γ-irradiation versus 600 cGy 250 kVp x-irradiation
| . | 700 cGy 60Co γ-Irradiation . | 600 cGy 250 kVp x-Irradiation . |
|---|---|---|
| Neutropenia duration (days) | 14.8 ± 0.7 | 16.2 ± 0.4 |
| ANC nadir (μL−1) | 0 ± 0 | 8 ± 4 |
| ANC recovery (days) | 19.7 ± 0.5 | 21.7 ± 0.4 |
| Thrombocytopenia duration (days) | 11.9 ± 1.6 | 10.4 ± 0.8 |
| PLT nadir (μL−1) | 5 000 ± 600 | 3 000 ± 1 000 |
| PLT recovery (days) | 20.7 ± 1.4 | 20.7 ± 0.9 |
| . | 700 cGy 60Co γ-Irradiation . | 600 cGy 250 kVp x-Irradiation . |
|---|---|---|
| Neutropenia duration (days) | 14.8 ± 0.7 | 16.2 ± 0.4 |
| ANC nadir (μL−1) | 0 ± 0 | 8 ± 4 |
| ANC recovery (days) | 19.7 ± 0.5 | 21.7 ± 0.4 |
| Thrombocytopenia duration (days) | 11.9 ± 1.6 | 10.4 ± 0.8 |
| PLT nadir (μL−1) | 5 000 ± 600 | 3 000 ± 1 000 |
| PLT recovery (days) | 20.7 ± 1.4 | 20.7 ± 0.9 |
Monkeys were total body irradiated to 700 cGy with60Co γ-irradiation (n = 10) or 600 cGy with 250 kVp x-irradiation (n = 11) as midline tissue doses and treated with control protein (HSA or autologous serum) according to protocol (Methods). Neutropenia is defined as an absolute neutrophil count (ANC) <500/μL and thrombocytopenia is defined as a platelet count (PLT) <20 000/μL. ANC and PLT recovery are the days required to reach sustained levels of ANC ≥500/μL and PLT ≥20 000/μL. Data represents mean values ± SEM.