Potential sickle red blood cell–vessel wall adhesion pathways
| Endothelial Cell . | Adhesive Bridging Protein . | SS RBC . |
|---|---|---|
| αVβ3 | ←——— TSP ———→ | sulfated glycolipid |
| αVβ3 | ←——— vWf ———→ | sulfated glycolipid |
| αVβ3 | ←——— TSP ———→ | CD36 |
| VCAM-1 | ←————————→ | α4β1 |
| CD36 | ←——— TSP ———→ | CD36 |
| GPIb | ←——— vWf ———→ | sulfated glycolipid |
| ? | ←————————→ | band 3 |
| Subendothelial Matrix | SS RBC | |
| vWf | ←————————→ | sulfated glycolipid |
| TSP | ←————————→ | sulfated glycolipid |
| LN | ←————————→ | sulfated glycolipid |
| FN | ←————————→ | α4β1 |
| LN | ←————————→ | B-CAM/LU |
| Endothelial Cell . | Adhesive Bridging Protein . | SS RBC . |
|---|---|---|
| αVβ3 | ←——— TSP ———→ | sulfated glycolipid |
| αVβ3 | ←——— vWf ———→ | sulfated glycolipid |
| αVβ3 | ←——— TSP ———→ | CD36 |
| VCAM-1 | ←————————→ | α4β1 |
| CD36 | ←——— TSP ———→ | CD36 |
| GPIb | ←——— vWf ———→ | sulfated glycolipid |
| ? | ←————————→ | band 3 |
| Subendothelial Matrix | SS RBC | |
| vWf | ←————————→ | sulfated glycolipid |
| TSP | ←————————→ | sulfated glycolipid |
| LN | ←————————→ | sulfated glycolipid |
| FN | ←————————→ | α4β1 |
| LN | ←————————→ | B-CAM/LU |
SS RBC, sickle red blood cell; TSP, thrombospondin; vWf, von Willebrand factor; VCAM-1, vascular cell adhesion molecule-1; GPIb, glycoprotein Ib; FN, fibronectin; LN, laminin; B-CAM/LU, basal cell adhesion molecule/lutheran protein.