Correction of hemophilic phenotype by MiniAdFVIII in mouse models
| Group . | Treatment . | hFVIII Expression* (ng/mL) . | Capillary Tube Clotting Test (min) . | Tail Clip Blood Flow Rate (μL/min) . | Tail Clip Bleeding Time (min) . |
|---|---|---|---|---|---|
| Hemophilic mice | 2.5 × 1011 vp | 104 ± 26 | 2.58 ± 0.51 | 8.6 ± 1.07 | 30.7 ± 11.8 |
| Hemophilic mice | Vehicle | ND | 5.30 ± 1.87 | 20.9 ± 4.39 | No clotting |
| C57BL/6 | None | ND | 3.40 ± 0.69 | 4.8 ± 0.86 | 11.2 ± 6.6 |
| Group . | Treatment . | hFVIII Expression* (ng/mL) . | Capillary Tube Clotting Test (min) . | Tail Clip Blood Flow Rate (μL/min) . | Tail Clip Bleeding Time (min) . |
|---|---|---|---|---|---|
| Hemophilic mice | 2.5 × 1011 vp | 104 ± 26 | 2.58 ± 0.51 | 8.6 ± 1.07 | 30.7 ± 11.8 |
| Hemophilic mice | Vehicle | ND | 5.30 ± 1.87 | 20.9 ± 4.39 | No clotting |
| C57BL/6 | None | ND | 3.40 ± 0.69 | 4.8 ± 0.86 | 11.2 ± 6.6 |
Two groups of 12 hemophilic mice received 2.5 × 1011viral particle (vp)/mouse or vehicle, respectively. On PI day 3, a clotting test was performed. On PI day 6, tail clip tests were carried out.
Sampled on PI day 6. ND, no detection.