Summary of expression patterns of some B-cell-associated chemokine receptors
| Receptor . | Expression in Normal B Cells . | Low/Absent Expression . | Expression in Lymphoma . | References . |
|---|---|---|---|---|
| CXCR3 | Subset of B cells in blood | Nodal/splenic B cells | CLL, SMZL, PC, MALT ± HCL | Table I, 21, 22 |
| CXCR4 | Pre-B and mature B cells | Plasma cells | ALL and other subtypes | 23-25, 34 |
| BLR1/CXCR5 | Mature/unstimulated B cells mantle, primary follicle | Immature B activated B cells | B cell lymphomas of all types | Table II, 12, 19, 26, 27, 35 |
| CCR6 | Most peripheral B cells | Not reported | 9, 11 | |
| BLR2/CCR7 | Mature B | Immature B | Not reported | 15, 28-31 |
| Receptor . | Expression in Normal B Cells . | Low/Absent Expression . | Expression in Lymphoma . | References . |
|---|---|---|---|---|
| CXCR3 | Subset of B cells in blood | Nodal/splenic B cells | CLL, SMZL, PC, MALT ± HCL | Table I, 21, 22 |
| CXCR4 | Pre-B and mature B cells | Plasma cells | ALL and other subtypes | 23-25, 34 |
| BLR1/CXCR5 | Mature/unstimulated B cells mantle, primary follicle | Immature B activated B cells | B cell lymphomas of all types | Table II, 12, 19, 26, 27, 35 |
| CCR6 | Most peripheral B cells | Not reported | 9, 11 | |
| BLR2/CCR7 | Mature B | Immature B | Not reported | 15, 28-31 |
PC, plasmacytoma, MALT, extranodal marginal zone lymphoma.