CXCR3 and Mig expression in B-cell tumors
| Tumor Type . | CXCR3 by IHC . | CXCR3 by Flow . | Mig by IHC . |
|---|---|---|---|
| Lymphoblastic leukemia/lymphoma | 3/9 (2 focal, 1 diffuse) | nd | nd |
| Small noncleaved cell lymphoma (Burkitt's/L3 ALL) | 0/8† | nd | 1/4 |
| Chronic lymphocytic leukemia/small lymphocytic lymphoma | 34/36 (30 diffuse) | 12/13 | 10/13 (5 diffuse) |
| CLL in transformation | 4/6 | 1/1 | 2/3 |
| Prolymphocytic leukemia | 1/3 | nd | 2/2 |
| Hairy cell leukemia | 5/7 | 1/1 | nd |
| Mantle cell lymphoma | 1/30† | 0/2 | 2/12 |
| Follicular lymphoma‡ | 1/27 (focal)† | 0/1 | 2/16 |
| Splenic marginal zone lymphoma | 14/14 | nd | 4/8 |
| Extranodal marginal zone lymphoma | 15/16* | nd | 3/3 |
| Plasmacytoma | 5/8 | nd | 1/1 |
| Large cell lymphoma | 5/33 (3 diffuse; all splenic) | nd | 2/3 |
| Tumor Type . | CXCR3 by IHC . | CXCR3 by Flow . | Mig by IHC . |
|---|---|---|---|
| Lymphoblastic leukemia/lymphoma | 3/9 (2 focal, 1 diffuse) | nd | nd |
| Small noncleaved cell lymphoma (Burkitt's/L3 ALL) | 0/8† | nd | 1/4 |
| Chronic lymphocytic leukemia/small lymphocytic lymphoma | 34/36 (30 diffuse) | 12/13 | 10/13 (5 diffuse) |
| CLL in transformation | 4/6 | 1/1 | 2/3 |
| Prolymphocytic leukemia | 1/3 | nd | 2/2 |
| Hairy cell leukemia | 5/7 | 1/1 | nd |
| Mantle cell lymphoma | 1/30† | 0/2 | 2/12 |
| Follicular lymphoma‡ | 1/27 (focal)† | 0/1 | 2/16 |
| Splenic marginal zone lymphoma | 14/14 | nd | 4/8 |
| Extranodal marginal zone lymphoma | 15/16* | nd | 3/3 |
| Plasmacytoma | 5/8 | nd | 1/1 |
| Large cell lymphoma | 5/33 (3 diffuse; all splenic) | nd | 2/3 |
Focal staining corresponds to staining in 10% or fewer tumor cells.
Positive in plasma cells, lymphoplasmacytic forms and B cells with monocytoid appearance.
P < .0001 by Fisher's exact test, comparing CXCR3 expression to that seen in B-CLL.
Includes 16 small cell, 4 mixed small and large cell, and 7 large cell types.