Engraftment of selected Ph1-ALL cells into NOD/SCID mice
| Patient No. . | CD34− . | CD34+ . | CD34+ CD38+ . | CD34++CD38− . |
|---|---|---|---|---|
| 1 | <1 | 2 ± 0.5 | <1 | 6 ± 0.4 |
| 2 | <1 | 8 ± 0.7 | <1 | 9 ± 0.8 |
| 3 | <1 | 12 ± 1 | <1 | 10.5 ± 0.9 |
| 4 | <1 | 7.5 ± 0.4 | — | — |
| 5 | <1 | 9 ± 0.9 | <1 | 8.5 ± 0.7 |
| 6 | <1 | 6 ± 0.5 | <1 | 6 ± 0.4 |
| 7 | <1 | 11 ± 1.1 | <1 | 9.5 ± 0.8 |
| Patient No. . | CD34− . | CD34+ . | CD34+ CD38+ . | CD34++CD38− . |
|---|---|---|---|---|
| 1 | <1 | 2 ± 0.5 | <1 | 6 ± 0.4 |
| 2 | <1 | 8 ± 0.7 | <1 | 9 ± 0.8 |
| 3 | <1 | 12 ± 1 | <1 | 10.5 ± 0.9 |
| 4 | <1 | 7.5 ± 0.4 | — | — |
| 5 | <1 | 9 ± 0.9 | <1 | 8.5 ± 0.7 |
| 6 | <1 | 6 ± 0.5 | <1 | 6 ± 0.4 |
| 7 | <1 | 11 ± 1.1 | <1 | 9.5 ± 0.8 |
Groups of 8-10 mice were transplanted with 2 × 105purified CD34+, CD34−, or CD34+CD38+ cells and 0.2 × 105CD34++CD38− cells. Human cell engraftment was estimated by Southern blot analysis 4-6 weeks later, as previously described.