Hematocrit and white blood cell counts in double mutant mice
| . | Genotype . | |||||||
|---|---|---|---|---|---|---|---|---|
| Wild Type . | LIF−/− . | IL-6−/− . | IL-11Ra−/− . | mpl−/− . | mpl−/− LIF−/− . | mpl−/− IL-6−/− . | mpl−/− IL-11Ra−/− . | |
| Hematocrit (%) | 53 ± 2 | 49 ± 2 | 51 ± 3 | 48 ± 1* | 50 ± 2 | 49 ± 4 | 51 ± 1 | 48 ± 2 |
| White cell count (×10−6/mL) | 4.7 ± 1.5 | 6.6 ± 1.9 | 3.5 ± 1.2 | 8.2 ± 2.7* | 3.9 ± 1.2 | 6.5 ± 2.4 | 4.3 ± 1.2 | 6.7 ± 2.0 |
| Neutrophils (%) | 7 ± 2 | 15 ± 2 | 11 ± 4 | 15 ± 8 | 9 ± 9 | 16 ± 10 | 17 ± 16 | 14 ± 13 |
| Lymphocytes (%) | 84 ± 4 | 80 ± 1 | 84 ± 4 | 76 ± 9 | 86 ± 10 | 78 ± 9 | 75 ± 20 | 82 ± 14 |
| Monocytes (%) | 7 ± 4 | 4 ± 1 | 3 ± 1 | 8 ± 4 | 4 ± 3 | 5 ± 3 | 7 ± 5 | 3 ± 2 |
| Eosinophils (%) | 2 ± 2 | 1 ± 1 | 2 ± 1 | 1 ± 1 | 1 ± 1 | 1 ± 1 | 1 ± 1 | 1 ± 1 |
| . | Genotype . | |||||||
|---|---|---|---|---|---|---|---|---|
| Wild Type . | LIF−/− . | IL-6−/− . | IL-11Ra−/− . | mpl−/− . | mpl−/− LIF−/− . | mpl−/− IL-6−/− . | mpl−/− IL-11Ra−/− . | |
| Hematocrit (%) | 53 ± 2 | 49 ± 2 | 51 ± 3 | 48 ± 1* | 50 ± 2 | 49 ± 4 | 51 ± 1 | 48 ± 2 |
| White cell count (×10−6/mL) | 4.7 ± 1.5 | 6.6 ± 1.9 | 3.5 ± 1.2 | 8.2 ± 2.7* | 3.9 ± 1.2 | 6.5 ± 2.4 | 4.3 ± 1.2 | 6.7 ± 2.0 |
| Neutrophils (%) | 7 ± 2 | 15 ± 2 | 11 ± 4 | 15 ± 8 | 9 ± 9 | 16 ± 10 | 17 ± 16 | 14 ± 13 |
| Lymphocytes (%) | 84 ± 4 | 80 ± 1 | 84 ± 4 | 76 ± 9 | 86 ± 10 | 78 ± 9 | 75 ± 20 | 82 ± 14 |
| Monocytes (%) | 7 ± 4 | 4 ± 1 | 3 ± 1 | 8 ± 4 | 4 ± 3 | 5 ± 3 | 7 ± 5 | 3 ± 2 |
| Eosinophils (%) | 2 ± 2 | 1 ± 1 | 2 ± 1 | 1 ± 1 | 1 ± 1 | 1 ± 1 | 1 ± 1 | 1 ± 1 |
Mean ± SD, n = 2 to 9 mice of each genotype.
P < .05 for comparison of data from LIF−/−, IL-6−/−, or IL-11Rα−/− mice with wild-type controls or of LIF−/− mpl−/−, IL-6−/− mpl−/−, or IL-11Rα−/− mpl−/− mice with mpl−/− data. No other statistically significant differences were observed.