Table 6. Distribution of genetic lesions... | American Society of Hematology

Table 6.

Distribution of genetic lesions in different subsets of B-lineage diffuse large cell lymphoma (B-DLCL) with and without BCL-6 mutations

B-DLCL Subset	BCL-6 R^6-150,^6-151	c-MYC R^6-150,^6-151	BCL-2 R^6-150,^6-151	p53 M^6-150,^6-151	EBV^6-150
Systemic de novo B-DLCL
with BCL-6 mutations	11/33	0/32	3/33	2/32	0/31
withoutBCL-6 mutations	9/33	1/32	9/33	4/31	0/31
Transformed B-DLCL
with BCL-6 mutations	0/3	0/3	3/3	3/3	0/3
without BCL-6 mutations	0/2	0/2	2/2	2/2	0/2
Primary mediastinal B-DLCL with sclerosis
with BCL-6 mutations	n.d.^§	n.d.	0/1	1/1	1/1
without BCL-6 mutations	0/8	n.d.	0/9	2/9	0/9
CD5⁺ B-DLCL
withBCL-6 mutations	0/1	0/1	0/1	0/1	0/1
without BCL-6 mutations	0/1	0/1	0/1	0/1	0/1
Primary splenic B-DLCL
with BCL-6 mutations	1/9	0/9	0/9	1/9	0/9
withoutBCL-6 mutations	1/6	1/6	1/6	1/6	0/6
Primary extranodal B-DLCL^6-155
with BCL-6 mutations	5/7	0/7	0/7	1/7	0/7
withoutBCL-6 mutations	1/5	0/5	0/5	1/5	0/5
CD30⁺ anaplastic B-DLCL
with BCL-6 mutations	1/2	1/2	0/2	0/2	0/2
withoutBCL-6 mutations	0/2	0/2	0/2	0/2	0/2
Primary central nervous system B-DLCL
with BCL-6 mutations	0/2	0/2	0/2	0/2	0/2
withoutBCL-6 mutations	0/1	0/1	0/1	0/1	0/1

B-DLCL Subset	BCL-6 R^6-150,^6-151	c-MYC R^6-150,^6-151	BCL-2 R^6-150,^6-151	p53 M^6-150,^6-151	EBV^6-150
Systemic de novo B-DLCL
with BCL-6 mutations	11/33	0/32	3/33	2/32	0/31
withoutBCL-6 mutations	9/33	1/32	9/33	4/31	0/31
Transformed B-DLCL
with BCL-6 mutations	0/3	0/3	3/3	3/3	0/3
without BCL-6 mutations	0/2	0/2	2/2	2/2	0/2
Primary mediastinal B-DLCL with sclerosis
with BCL-6 mutations	n.d.^§	n.d.	0/1	1/1	1/1
without BCL-6 mutations	0/8	n.d.	0/9	2/9	0/9
CD5⁺ B-DLCL
withBCL-6 mutations	0/1	0/1	0/1	0/1	0/1
without BCL-6 mutations	0/1	0/1	0/1	0/1	0/1
Primary splenic B-DLCL
with BCL-6 mutations	1/9	0/9	0/9	1/9	0/9
withoutBCL-6 mutations	1/6	1/6	1/6	1/6	0/6
Primary extranodal B-DLCL^6-155
with BCL-6 mutations	5/7	0/7	0/7	1/7	0/7
withoutBCL-6 mutations	1/5	0/5	0/5	1/5	0/5
CD30⁺ anaplastic B-DLCL
with BCL-6 mutations	1/2	1/2	0/2	0/2	0/2
withoutBCL-6 mutations	0/2	0/2	0/2	0/2	0/2
Primary central nervous system B-DLCL
with BCL-6 mutations	0/2	0/2	0/2	0/2	0/2
withoutBCL-6 mutations	0/1	0/1	0/1	0/1	0/1

Positive/tested;

R, rearrangement; M, mutation;

B-DLCL derived from histologic transformation of a previous follicular lymphoma;

n.d., not done;

B-DLCL presenting in extranodal sites without evidence of nodal involvement at diagnosis.