Comparative analysis of BCL-6 and IgvH mutations in selected B-cell malignancies
| Histology . | BCL-6M/IgVM 5-150 . | BCL-6G/IgVM 5-150 . | BCL-6G/IgVG 5-150 . | Mean Frequency of Mutation (range) . | |
|---|---|---|---|---|---|
| BCL-6 . | IgVH . | ||||
| Follicular lymphoma (n = 15) | 9/15 (60.0%) | 6/15 (40.0%) | 0/15 | 0.83 × 10−2 bp | 9.8 × 10−2bp |
| (0.27-1.1) | (5.4-18.2) | ||||
| MALT lymphoma (n = 15) | 5/15 (33.3%) | 10/15 (66.7%) | 0/15 | 0.75 × 10−2 bp | 8.1 × 10−2bp |
| (0.27-1.9) | (3.2-15.5) | ||||
| Hairy cell leukemia (n = 8) | 2/8 (25.0%) | 4/8 (50.0%) | 2/8 (25.0%) | 0.27 × 10−2 bp | 6.9 × 10−2 bp |
| (0.13-0.40) | (3.3-10.8) | ||||
| Histology . | BCL-6M/IgVM 5-150 . | BCL-6G/IgVM 5-150 . | BCL-6G/IgVG 5-150 . | Mean Frequency of Mutation (range) . | |
|---|---|---|---|---|---|
| BCL-6 . | IgVH . | ||||
| Follicular lymphoma (n = 15) | 9/15 (60.0%) | 6/15 (40.0%) | 0/15 | 0.83 × 10−2 bp | 9.8 × 10−2bp |
| (0.27-1.1) | (5.4-18.2) | ||||
| MALT lymphoma (n = 15) | 5/15 (33.3%) | 10/15 (66.7%) | 0/15 | 0.75 × 10−2 bp | 8.1 × 10−2bp |
| (0.27-1.9) | (3.2-15.5) | ||||
| Hairy cell leukemia (n = 8) | 2/8 (25.0%) | 4/8 (50.0%) | 2/8 (25.0%) | 0.27 × 10−2 bp | 6.9 × 10−2 bp |
| (0.13-0.40) | (3.3-10.8) | ||||
BCL-6M/IgVM, cases harboring mutated BCL-6 and IgVH genes;BCL-6G/IgVM, cases harboring germlineBCL-6 genes and mutated IgVH genes;BCL-6G/IgVG, cases harboring germlineBCL-6 and IgVH genes. For each category, the number of positive/tested cases is indicated.