Table 3. Normalized frequency of BCL -6... | American Society of Hematology

Table 3.

Normalized frequency of BCL-6 mutations according to the type of single nucleotide substitution

Type of Nucleotide Substitution	Number of Mutations Observed	% of Total Mutations Observed	P^3-150,^3-151
Transitions and transversions
T → N	68	29.4	n.s.
C → N	49	28.7	n.s.
G → N	51	27.5	n.s.
A → N	17	14.4	<.01
Transitions
G → A	28	15.1	<.001
A → G	7	5.90	n.s.
T → C	30	13.0	<.05
C → T	18	10.5	n.s.
Transversions
C → G	24	14.0	<.01
G → C	20	10.8	n.s.
T → G	20	8.70	n.s.
T → A	18	7.80	n.s.
C → A	7	4.10	<.05
A → T	5	4.20	<.05
A → C	5	4.20	<.05
G → T	3	1.60	<.005

Type of Nucleotide Substitution	Number of Mutations Observed	% of Total Mutations Observed	P^3-150,^3-151
Transitions and transversions
T → N	68	29.4	n.s.
C → N	49	28.7	n.s.
G → N	51	27.5	n.s.
A → N	17	14.4	<.01
Transitions
G → A	28	15.1	<.001
A → G	7	5.90	n.s.
T → C	30	13.0	<.05
C → T	18	10.5	n.s.
Transversions
C → G	24	14.0	<.01
G → C	20	10.8	n.s.
T → G	20	8.70	n.s.
T → A	18	7.80	n.s.
C → A	7	4.10	<.05
A → T	5	4.20	<.05
A → C	5	4.20	<.05
G → T	3	1.60	<.005

F3-150

Calculated with χ² test; n.s., not significant.

F3-151

The following nucleotide changes occurred more frequently than expected: G → A, T → C, and C → G. The following nucleotide changes occurred less frequently than expected: C → A, A → T, A → C, and G → T.

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