Distribution of BCL-6 mutations throughout the spectrum of B-cell neoplasia
| Histology . | BCL-6 Mutations (positive/tested)* . |
|---|---|
| Precursor B-cell neoplasms | |
| Acute lymphoblastic leukemia† | 0/46 (0%) (P < .001) |
| Peripheral B-cell neoplasms | |
| B-cell chronic lymphocytic leukemia | 9/30 (30.0%) |
| Small lymphocytic lymphoma | 2/9 (22.2%) |
| Lymphoplasmacytoid lymphoma | 2/5 (40.0%) |
| Mantle cell lymphoma | 2/20 (10.0%) (P < .05) |
| Follicular lymphoma | 9/15 (60.0%) |
| MALT lymphoma | 5/15 (33.3%) |
| Hairy cell leukemia | 2/8 (25.0%) |
| B-lineage diffuse large cell lymphoma‡ | 61/125 (48.8%) |
| Burkitt lymphoma | 13/35 (37.1%) |
| Histology . | BCL-6 Mutations (positive/tested)* . |
|---|---|
| Precursor B-cell neoplasms | |
| Acute lymphoblastic leukemia† | 0/46 (0%) (P < .001) |
| Peripheral B-cell neoplasms | |
| B-cell chronic lymphocytic leukemia | 9/30 (30.0%) |
| Small lymphocytic lymphoma | 2/9 (22.2%) |
| Lymphoplasmacytoid lymphoma | 2/5 (40.0%) |
| Mantle cell lymphoma | 2/20 (10.0%) (P < .05) |
| Follicular lymphoma | 9/15 (60.0%) |
| MALT lymphoma | 5/15 (33.3%) |
| Hairy cell leukemia | 2/8 (25.0%) |
| B-lineage diffuse large cell lymphoma‡ | 61/125 (48.8%) |
| Burkitt lymphoma | 13/35 (37.1%) |
Statistically significant differences in BCL-6 mutation frequency are indicated by the corresponding P-value.
Cases of precursor B-cell acute lymphoblastic leukemia were representative of different molecular variants of the disease and included cases associated with hyperdiploidy (n = 5), rearrangement of BCR/ABL (n = 13), rearrangement of MLL (n = 9), rearrangement of TEL/AML-1 (n = 6), or no known genetic lesion (n = 13).
The representation of the different subsets of B-lineage diffuse large cell lymphoma included in this study is reported in Table 2.