Analysis of prognostic impact of clinical and biological characteristics
| Characteristics . | No. of Patients . | pEFS at 5 Years . | p Log-Rank . |
|---|---|---|---|
| Gender | |||
| Female | 24 | 83% ± 8% | |
| Male | 81 | 94% ± 3% | 0.15 |
| Age | |||
| Under 10 years | 57 | 89% ± 4% | |
| 10 years and older | 48 | 94% ± 3% | 0.72 |
| Stage of disease | |||
| Stage III | 82 | 90% ± 3% | |
| Stage IV | 19 | 95% ± 5% | 0.49 |
| LDH* | |||
| Less than 500 U/L | 57 | 89% ± 4% | |
| 500 U/L and above | 44 | 95% ± 2% | 0.41 |
| Immunophenotype | |||
| Pro-/pre-T-cell | 11 | 82% ± 9% | |
| Intermediate T-cell | 42 | 93% ± 4% | 2-153 |
| Mature T-cell | 6 | 100% | |
| T-cell, not further specified | 46 | 91% ± 4% | |
| Complete tumor response on day 33† | |||
| Yes | 64 | 95% ± 2% | |
| No | 37 | 89% ± 5% | 0.37 |
| Residual tumor on end of induction‡ | |||
| No | 80 | 95% ± 2% | |
| Yes | 19 | 89% ± 5% | 0.58 |
| Characteristics . | No. of Patients . | pEFS at 5 Years . | p Log-Rank . |
|---|---|---|---|
| Gender | |||
| Female | 24 | 83% ± 8% | |
| Male | 81 | 94% ± 3% | 0.15 |
| Age | |||
| Under 10 years | 57 | 89% ± 4% | |
| 10 years and older | 48 | 94% ± 3% | 0.72 |
| Stage of disease | |||
| Stage III | 82 | 90% ± 3% | |
| Stage IV | 19 | 95% ± 5% | 0.49 |
| LDH* | |||
| Less than 500 U/L | 57 | 89% ± 4% | |
| 500 U/L and above | 44 | 95% ± 2% | 0.41 |
| Immunophenotype | |||
| Pro-/pre-T-cell | 11 | 82% ± 9% | |
| Intermediate T-cell | 42 | 93% ± 4% | 2-153 |
| Mature T-cell | 6 | 100% | |
| T-cell, not further specified | 46 | 91% ± 4% | |
| Complete tumor response on day 33† | |||
| Yes | 64 | 95% ± 2% | |
| No | 37 | 89% ± 5% | 0.37 |
| Residual tumor on end of induction‡ | |||
| No | 80 | 95% ± 2% | |
| Yes | 19 | 89% ± 5% | 0.58 |
Data lacking from 4 patients.
Four patients excluded: 1 patient due to early death, 2 patients due to therapy deviation, 1 patient due to lack of required follow-up observation.
Two patients with less than 70% tumor regression at day 33 who continued on ALL-high-risk therapy excluded.
p log-rank >0.2 in all comparisons.