Molecular data of V-form APL cases on Intergroup 0129
| Case . | Exon 6 Break* . | Inserted Nucleotides & Amino Acids† . |
|---|---|---|
| C132 | −146 | gaggagtccttctgcaggaagaggagagattgcca |
| ArgSerProSerAlaGlyArgGlyGluIleAla | ||
| C205 | −142 | tcctcccctcttctctctctagcca |
| SerSerProLeuLeuSerLeuAla | ||
| S448 | −78 | ctatggacacacaggttggagcca |
| MetAspThrGlnValGlyAla | ||
| S444 | −77 | tagtcttagagcca |
| SerLeuArgAla | ||
| E076 | −61 | gtctgccatcctaaccttccatcttggcaaggggcactgggtcct |
| ValCysHisProAsnLeuProSerTrpGlnGlyAlaLeuGlyPro | ||
| tatggggttgttgtcctggccccagacacttggctgtcatctttg | ||
| TyrGlyValValValLeuAlaProAspThrTrpLeuSerSerLeu | ||
| aggctttcatccccaggagtggaggggagaagctgctctgcca | ||
| ArgLeuSerSerProGlyValGluGlyArgSerCysSerAla | ||
| C902 | −54 | gaacca |
| E003 | Thr | |
| E011 | ||
| E801 | ||
| E036 | −37 | cccgaaggactggacacacaggttggagcca |
| ProGluGlyLeuAspThrGluValGlyAla | ||
| E086 | −30 | gcagagcca |
| ArgAla | ||
| S386 | −28 | aacgcccggcacacatacaaatcca |
| AsnAlaArgHisThrTyrLysSer | ||
| E805 | −24 | acggagccacca |
| GlyArgThr | ||
| C179 | −23 | cgtactctttcttagagcca |
| ValLeuPheLeuArgAla | ||
| E027 | −21 | tgggagcca |
| GlyAla | ||
| E091 | −12 | gcgcca |
| Ala | ||
| C183 | −10 | gccaccccgctccggactccgctttggaatggctcaaaccactcca |
| AlaThrProLeuArgThrProLeuTrpAsnGlySerAsnHisSer | ||
| E070 | −8 | cggagtttgggcca |
| GlyValTrpAla |
| Case . | Exon 6 Break* . | Inserted Nucleotides & Amino Acids† . |
|---|---|---|
| C132 | −146 | gaggagtccttctgcaggaagaggagagattgcca |
| ArgSerProSerAlaGlyArgGlyGluIleAla | ||
| C205 | −142 | tcctcccctcttctctctctagcca |
| SerSerProLeuLeuSerLeuAla | ||
| S448 | −78 | ctatggacacacaggttggagcca |
| MetAspThrGlnValGlyAla | ||
| S444 | −77 | tagtcttagagcca |
| SerLeuArgAla | ||
| E076 | −61 | gtctgccatcctaaccttccatcttggcaaggggcactgggtcct |
| ValCysHisProAsnLeuProSerTrpGlnGlyAlaLeuGlyPro | ||
| tatggggttgttgtcctggccccagacacttggctgtcatctttg | ||
| TyrGlyValValValLeuAlaProAspThrTrpLeuSerSerLeu | ||
| aggctttcatccccaggagtggaggggagaagctgctctgcca | ||
| ArgLeuSerSerProGlyValGluGlyArgSerCysSerAla | ||
| C902 | −54 | gaacca |
| E003 | Thr | |
| E011 | ||
| E801 | ||
| E036 | −37 | cccgaaggactggacacacaggttggagcca |
| ProGluGlyLeuAspThrGluValGlyAla | ||
| E086 | −30 | gcagagcca |
| ArgAla | ||
| S386 | −28 | aacgcccggcacacatacaaatcca |
| AsnAlaArgHisThrTyrLysSer | ||
| E805 | −24 | acggagccacca |
| GlyArgThr | ||
| C179 | −23 | cgtactctttcttagagcca |
| ValLeuPheLeuArgAla | ||
| E027 | −21 | tgggagcca |
| GlyAla | ||
| E091 | −12 | gcgcca |
| Ala | ||
| C183 | −10 | gccaccccgctccggactccgctttggaatggctcaaaccactcca |
| AlaThrProLeuArgThrProLeuTrpAsnGlySerAsnHisSer | ||
| E070 | −8 | cggagtttgggcca |
| GlyValTrpAla |
Extent of PML exon 6 truncation (0 = no loss of PML exon 6 sequence).
Inserted or novel nucleotides and amino acids (in 3-letter code) are shown in bold type, preceded by the last 3 nucleotides of truncated PML exon 6 and followed by the first 3 nucleotides (cca) of RARα exon 3. In cases with no insertions (C902, E003, E011, E801, and E091), the junctional amino acid is in italics.