Stats in hematopoiesis: phenotypes of mouse knockouts
| Stat Type . | Relevant Phenotypes . | Cytokines Affected . | Refs . |
|---|---|---|---|
| Stat1 | • Interferon responses absent: — innate immune responses absent — highly sensitive to viral/microbial infection — IFN-responsive genes not activated | IFNs only | 22, 23 |
| Stat 2 | • Type 1 interferon responses impaired | IFN-α/β | C. Schindler, pers. comm. |
| Stat 3 | • Embryonic lethal | 24 | |
| Stat 4 | • IL-12 responses absent ↓ production of high IFN-γ, low IFN-γ Rα Th1 cells ↓ priming for high level IFN-γ production ↓ lymphocyte proliferation ↓ enhancement of NK cell-mediated cytotoxicity ↑ Th2 cells | IL-12 only | 26, 27 |
| Stat5ab | • Proliferation signaling affected: ↓ CFU-Mix, Eos, G, GM, Pre-B ↓ peripheral T cells Absence of NK cells | IL-2, IL-3, IL-7, GM-CSF, G-CSF | 28, 29 |
| Stat6 | • IL-4 responses absent: -Absence of IL-4 producing Th2 cells -Block in B-cell IgE class switching ↓ lymphocyte proliferation (partial) ↓ expression of IL-4-induced cell surface markers | IL-4 only | 32, 33, 179 |
| Stat Type . | Relevant Phenotypes . | Cytokines Affected . | Refs . |
|---|---|---|---|
| Stat1 | • Interferon responses absent: — innate immune responses absent — highly sensitive to viral/microbial infection — IFN-responsive genes not activated | IFNs only | 22, 23 |
| Stat 2 | • Type 1 interferon responses impaired | IFN-α/β | C. Schindler, pers. comm. |
| Stat 3 | • Embryonic lethal | 24 | |
| Stat 4 | • IL-12 responses absent ↓ production of high IFN-γ, low IFN-γ Rα Th1 cells ↓ priming for high level IFN-γ production ↓ lymphocyte proliferation ↓ enhancement of NK cell-mediated cytotoxicity ↑ Th2 cells | IL-12 only | 26, 27 |
| Stat5ab | • Proliferation signaling affected: ↓ CFU-Mix, Eos, G, GM, Pre-B ↓ peripheral T cells Absence of NK cells | IL-2, IL-3, IL-7, GM-CSF, G-CSF | 28, 29 |
| Stat6 | • IL-4 responses absent: -Absence of IL-4 producing Th2 cells -Block in B-cell IgE class switching ↓ lymphocyte proliferation (partial) ↓ expression of IL-4-induced cell surface markers | IL-4 only | 32, 33, 179 |
CFU, colony-forming unit: G-CSF, granulocyte colony-stimulating factor; GM-CSF, granulocyte-macrophage colony-stimulating factor; IFN, interferon; IL, interleukin; NK, natural killer.