Jaks in hematopoiesis: phenotype of mouse knockouts
| Jak Type . | Relevant Phenotypes . | Cytokines Affected . | Refs . |
|---|---|---|---|
| Jak1 | • Impaired lymphoid development | IL-2, IL-4, IL-6, IL-7, IL-9, IL-10, IL-15, LIF, all interferons | 15 |
| • Defective responses to class 2 cytokines and those using γc or gp130 receptor subunits | |||
| Jak2 | • No definitive erythropoiesis | EPO, TPO, IL-3, IL-5, GM-CSF, IFN-γ | 16, 17 |
| Jak3 | • Defective lymphoid development | IL-4, IL-7, IL-9, IL-15 | 18-20 |
| • Dysregulated myelopoiesis |
| Jak Type . | Relevant Phenotypes . | Cytokines Affected . | Refs . |
|---|---|---|---|
| Jak1 | • Impaired lymphoid development | IL-2, IL-4, IL-6, IL-7, IL-9, IL-10, IL-15, LIF, all interferons | 15 |
| • Defective responses to class 2 cytokines and those using γc or gp130 receptor subunits | |||
| Jak2 | • No definitive erythropoiesis | EPO, TPO, IL-3, IL-5, GM-CSF, IFN-γ | 16, 17 |
| Jak3 | • Defective lymphoid development | IL-4, IL-7, IL-9, IL-15 | 18-20 |
| • Dysregulated myelopoiesis |
EPO, erythropoietin; IFN, interferon; IL, interleukin; TPO, thrombopoietin.