Table 1. Genes Involved in V(D)J... | American Society of Hematology

Table 1.

Genes Involved in V(D)J Recombination

Gene	Properties	Role in V(D)J Recombination	Other Roles
Rag-1	Endonuclease	Initiation	None known
Rag-2	Endonuclease	Initiation	None known
DNA-PKcs	Protein kinase	Rejoining coding ends	Switch recombination; DNA repair
Ku70	DNA end-binding; stimulates DNA ligase	Rejoining coding and signal ends	Switch recombination; DNA repair; growth
Ku86	DNA end-binding; stimulates DNA ligase; TdT recruitment	Rejoining coding and signal ends	Switch recombination; DNA repair; growth
XRCC4	Recruits DNA ligase	Rejoining coding and signal ends	DNA repair; brain development
DNA Ligase IV	End joining	Rejoining coding and signal ends	DNA repair; brain development
TdT	Template-independent base addition	Diversifies coding joints	None known

Gene	Properties	Role in V(D)J Recombination	Other Roles
Rag-1	Endonuclease	Initiation	None known
Rag-2	Endonuclease	Initiation	None known
DNA-PKcs	Protein kinase	Rejoining coding ends	Switch recombination; DNA repair
Ku70	DNA end-binding; stimulates DNA ligase	Rejoining coding and signal ends	Switch recombination; DNA repair; growth
Ku86	DNA end-binding; stimulates DNA ligase; TdT recruitment	Rejoining coding and signal ends	Switch recombination; DNA repair; growth
XRCC4	Recruits DNA ligase	Rejoining coding and signal ends	DNA repair; brain development
DNA Ligase IV	End joining	Rejoining coding and signal ends	DNA repair; brain development
TdT	Template-independent base addition	Diversifies coding joints	None known