Table 1.

Genes Involved in V(D)J Recombination

Gene Properties Role in V(D)J Recombination Other Roles
Rag-1  Endonuclease  Initiation  None known  
Rag-2 Endonuclease  Initiation  None known  
DNA-PKcs Protein kinase  Rejoining coding ends  Switch recombination; DNA repair  
Ku70  DNA end-binding; stimulates DNA ligase Rejoining coding and signal ends  Switch recombination; DNA repair; growth  
Ku86  DNA end-binding; stimulates DNA ligase; TdT recruitment  Rejoining coding and signal ends  Switch recombination; DNA repair; growth  
XRCC4  Recruits DNA ligase  Rejoining coding and signal ends  DNA repair; brain development  
DNA Ligase IV  End joining  Rejoining coding and signal ends  DNA repair; brain development  
TdT Template-independent base addition  Diversifies coding joints None known 
Gene Properties Role in V(D)J Recombination Other Roles
Rag-1  Endonuclease  Initiation  None known  
Rag-2 Endonuclease  Initiation  None known  
DNA-PKcs Protein kinase  Rejoining coding ends  Switch recombination; DNA repair  
Ku70  DNA end-binding; stimulates DNA ligase Rejoining coding and signal ends  Switch recombination; DNA repair; growth  
Ku86  DNA end-binding; stimulates DNA ligase; TdT recruitment  Rejoining coding and signal ends  Switch recombination; DNA repair; growth  
XRCC4  Recruits DNA ligase  Rejoining coding and signal ends  DNA repair; brain development  
DNA Ligase IV  End joining  Rejoining coding and signal ends  DNA repair; brain development  
TdT Template-independent base addition  Diversifies coding joints None known 
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